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10-25-2006, 02:13 PM | #31 | |||
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In Remembrance
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Quote:
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~Love, Sally . "The best way out is always through". Robert Frost ~If The World Didn't Suck, We Would All Fall Off~ |
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10-25-2006, 02:45 PM | #32 | ||
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Junior Member
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If you shorten the half life of Tysabri, it stays in the body for less time, not more. Azathioprine has an extremely short half-life itself, minutes, and its active derivatives have a half-life in the hours (1-3). I would be very surprised if it exerted any effect on the immune system months after discontinuation. |
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10-25-2006, 06:31 PM | #33 | |||
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In Remembrance
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BTW, Here is where I got the info. http://www.yourlawyer.com/articles/read/10734
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~Love, Sally . "The best way out is always through". Robert Frost ~If The World Didn't Suck, We Would All Fall Off~ |
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10-25-2006, 07:20 PM | #34 | ||
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Pantos,
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Harry |
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10-25-2006, 07:28 PM | #35 | ||
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Hi Sally,
Thanks for the link. You gotta remember though that those are only allegations made relating to a lawsuit, none of those things have been proven. Also the guy who claims it's not safe works for competing MS drug co's. I would really like to see the scientific research about whether Avonex with Tysabri increases the bioavailability of Tysabri or whether use of immunosupressants affect Tysabri's effects on the body. Could people who use Avonex use LESS Tysabri then to get the same effect but without going over to increasing the risks of developing infections? I am surprised the FDA allowed it back on the market before knowing this. Avonex is not really even considered an "immunosuppressant" so much as immuno-modulating. But given that MSer's often ARE given immunosuppressants which would seemingly have more effect at suppressing the immune system in conjunction with Tysabri, and given that the Crohn's patient had been OFF Azathioprine for a while yet still developed PML, I would think that we really need the answer to the question of what the risks are of developing PML having EVER used an immunosuppressant or immuno-modulator. Maybe the risks are still not huge given that we can assume that probably a fair # of people in the MS or Crohn's trials had used some kind of immunosuppressants at some point in their illness and only a very few developed PML. But how long does one need to wait to make sure that there is no contraindication occurring? What parameters put one at risk for PML? Is it even related to use of immune suppressants at all. I really wish we could know exactly WHAT puts someone at risk for PML. |
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10-25-2006, 07:32 PM | #36 | ||
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Hi Harry,
You slipped in there while I was writing my post. Well given that both MS and Crohn's patients are often prescribed immune suppressants, I would not think it was in Biogen's best interests to try to attribute the cases of PML to prior or current use of immunosuppressants. It doesn't make much financial sense given that so many patients HAVE used immunosuppressants (or immune modulators if Biogen wants to assert it was concomitant use of Avonex that caused PML). They'd be better off saying it was just an unknown and extremely rare result than blaming the use of immunosuppressants or modulators. |
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10-25-2006, 08:02 PM | #37 | ||
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But then again the strategy worked in pushing it through the FDA again.
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10-25-2006, 10:01 PM | #38 | |||
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When, in fact, you believe that the PML was caused by...what?
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. . rex |
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10-25-2006, 11:15 PM | #39 | ||
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The main problem that Biogen had then and still has now is that there are no real answers as to why these patients ended up getting PML. I'm sure that the company execs are holding their breath and really hoping that they don't hear the word "PML" for a very long time in conjunction with Tysabri use. Harry |
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10-26-2006, 01:24 AM | #40 | |||
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In Remembrance
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Sorry Sweety, come back and talk to us. I am truely interested in seeing you do well with Tysabri. Hugs,
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~Love, Sally . "The best way out is always through". Robert Frost ~If The World Didn't Suck, We Would All Fall Off~ |
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