The McDonald Criteria

Natalie8 · 05-18-2008, 09:43 PM

Quote:

Originally Posted by Quixotic1

Natalie, the Black Holes are seen in the T1-weighted images. They are the accumulation of areas of direct axonal (nerve fiber) degeneration. These correlate very well with both the accumulation of disability and with brain atrophy. Interesting enough, they are not so much the product of the inflammatory demyelinating and remyelinating lesions. So the Black Holes are NOT just the progression of the T2 lesions that the neuros talk about.

Quix

Thanks Quix. So if the black holes are not the progression of T2 lesions (which would show change over time) is this a separate process? How can I be told I have a bunch of black holes with my diagnosis 9 months ago but I have absolutely no disability at all and just the one incident of mild optic neuritis (where I still had 20/20 vision)?? Or is this just another example of how the MRI doesn't necessarily correlate with what is going clinically?

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