NeuroTalk Support Groups

NeuroTalk Support Groups (https://www.neurotalk.org/)

- Multiple Sclerosis (https://www.neurotalk.org/multiple-sclerosis/)

- - Vitamin D (https://www.neurotalk.org/multiple-sclerosis/53802-vitamin.html)

If one does a search on "multiple sclerosis mmp-9" the connection will be revealed.

I have the BEST presentation of this in a study in my Web Storage -

http://home.ix.netcom.com/~jdalton/Yongrev.pdf SEE FIGURE 2 page 505 and MS narrative

The Vit d3 connection and MMP-9s.

jackD

Quote:

1: QJM 2002 Dec;95(12):787-796

Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR
genotype: mechanisms for inflammatory damage in chronic disorders?
Timms PM, Mannan N, Hitman GA, Noonan K, Mills PG, Syndercombe-Court D,
Aganna E, Price CP, Boucher(2) BJ.
Departments of. Clinical Biochemistry, Diabetes and Metabolic Medicine and.
Haematology, Barts and The London, Queen Mary's School of Medicine and
Dentistry, University of London and. Department of Cardiology, 'Barts and
The London' NHS Trust, London, UK.

BACKGROUND:Vitamin-D deficiency and vitamin-D receptor genotype (VDR) are
risk factors for several disorders with inflammatory components, including
coronary heart disease (CHD) and diabetes, though the mechanisms involved
are unclear. Aim: To examine the hypothesis that vitamin D status modulates
the matrix metalloproteinase (MMP) system in a population with a high
prevalence of vitamin D deficiency, a situation affecting susceptibility to
CHD and diabetes.

DESIGN:
Prospective cross-sectional, interventional and embedded studies. METHODS:
Circulating MMP2,9, the inhibitor TIMP-1 and C-reactive protein (CRP) were
measured during studies of vitamin-D deficiency as a risk factor for type 2
diabetes and CHD in 171 healthy British Bangladeshi adults, free of known
diabetes or major illness. Vitamin D status, VDR genotype, body-build, blood
pressure, lipid and insulin profiles, glucose tolerance, fibrinogen, PAI-1,
folate and homocysteine were measured. Vitamin-D-deficient subjects were
re-assessed after 1 years' supplementation. MMP, TIMP-1 and CRP levels were
measured in 41 subjects halfway through 5-year follow-up. Independent
determinants of circulating concentrations of MMP9, TIMP-1 and CRP were
assessed by multiple regression analysis.

RESULTS: Vitamin D status was the sole determinant of circulating MMP9
(inversely) and an independent determinant of CRP (inversely). Determinants
of TIMP-1 were MMP9, systolic blood-pressure (directly) and VDR genotype
(TaqI). Significant reductions in MMP9 (-68%), TIMP-1 (-38%) and CRP (-23%)
concentrations followed vitamin-D supplementation.

DISCUSSION: Vitamin-D
insufficiency is associated with increased circulating MMP2,9 and CRP,
correctable by supplementation. This finding provides a possible mechanism
for tissue damage in chronic inflammatory conditions, including CHD and
diabetes.

PMID: 12454321

THE NGF thing is a bit more difficult to find.

jackD

***WARNING*** ***WARNING*** ***WARNING*** ***WARNING***

This site is for researchers ONLY!!!! Can cause mere mortals to go into shock!!!!

http://www.copewithcytokines.de/cope.cgi?key=NGF

Quote:

Vitamin D3 and some metabolically active precursors are potent inducers of the synthesis of NGF at concentrations of 100 picoM. This may have implications for the treatment of neurodegenerative diseases with NGF.

Another little tidbit found there that clarifies a lot of things

Quote:

The cytokines IL1, IL6, and bFGF are potent inducers of NGF. NGF induces the synthesis of IL1 in pheochromocytoma cells (see: PC12) which in turn acts as a growth factor for glial cells and induces the synthesis of NGF following nerve injuries.

Hi folks..I've read many of your posts about Vit D. I've had MS for over 20 years and am still learning from you all! My Vit D levels are low and yesterday my Primary Care Doc gave me rx for Vit D once a week.

My question is: Do any of you know why we with MS have low Vit D levels? What causes it?

Thanks!

Quote:

Originally Posted by jnewk (Post 771854)

I don't know what causes us to have lower levels of Vitamin D. Maybe someone who knows will come along soon and post about it.

What kind of Vitamin D did your doctor prescribe? If it's not D3 then it's pretty useless. Most doctors still prescribe D2 which, IMHO, is a total waste of money. D3 is available OTC and is relatively inexpensive.

Here is a link to a thread about Vitamin D: http://neurotalk.psychcentral.com/thread140053.html

Thanks for resurrecting this thread on Vitamin D because it is timely for me.

My wife has low Vitamin D and suffers from malaise, body fatigue, heavy limbs, and that "just not right bad feeling." She is now on a weekly OTC Vitamin D supplement in addition to a prescribed Vitamin D monthly.

My labs from April show a Vitamin D, 25-Hydroxy (?) level of 27.3 with a standard range of 32.0 - 100.0. My doctor has asked that I start taking an OTC Vitamin D supplement of 1000 iu daily. All other labs are well in line for normal.

Is this the same thing you are all discussing? What happens with a low Vitamin D level any way?

Quote:

Originally Posted by NeuroNixed Craig (Post 772025)

Please read the link Kitty gave above to my Vit D thread.

The RX version of D is D2 and is not very useful. Doctors still prescribe it but it just doesn't work. YOu need D3 OTC which is the active form to see any improvements and results. The D2 is a historical hold over from the past when D3 was not discovered.
D2 comes from plants and is not used by the body much. Doctors are not keeping up on this fact, and only are good for testing these days.

The rule today is 1000IU D3 to raise you 10 pts. Your target should be 50-70ng/ml. So if you are in the 30's you need 2000IU daily of D3. Get tested in 3 mons and adjust accordingly.

You are wasting precious time using the RX D2.

My thread has the new research and medical videos on this subject. So to see what benefits you can expect..the video from Univ. Medical School of Calif San Diego, and has the answers to that.
One of the most obvious is that you won't catch so many viruses and colds/flu. The other benefits are neurological among other things.

I'd also recommend you get a B12 test, since you cannot feel your toes when you cut your nails. In the same way, doctors report "normal" for very low ranges... which is no longer accurate. You should have at least 400 in US for your results. Anything lower needs supplements.
Here is the Medical link for doctors--(many have not learned this yet) from 2003... to correctly treat low B12 patients:
http://www.aafp.org/afp/2003/0301/p979.html
Low B12 impacts the entire nervous system, causing CNS effects similar to MS and peripheral neuropathies. It is very common in the elderly.

Medical doctors in US report "normal" for low B12 and Vit D because the lab ranges on the reports are OLD and no longer acceptable. A person can have significant neurological damage from B12 readings in the 200 or below range (which appears as "normal" on reports still).

Results of recent research into the effects of Vitamin D and MS were released today here in Australia. Here's a short synopsis.

"We found that higher levels of vitamin D are associated with a reduced likelihood of a relapse in MS."

"The study demonstrates that for each 10nmol/l* increase in serum vitamin D dosage, there was up to a 12 per cent reduction in the likelihood of a relapse."

"Clinically, raising vitamin D levels by 50nmol/l could halve the hazard of a relapse."

"Essentially, the study showed that people are more likely to have a relapse if they had low vitamin D levels."

Read more: http://www.menzies.utas.edu.au/artic...ntView&id=1291

Thanks, Koala!

For the US readers here, we measure the D differently than in Australia. They use nmols there and we use ng/ml

Here is a link to the conversion tables for countries using different report concentrations:

http://jama.ama-assn.org/site/misc/auinst_si.xhtml

Thanks Koala and mrsD! This information is invaluable. :)

I felt the best & progressed slowest taking 2000iu 4x/day. Level was 120's.