I've had MS since at least 2004, dx in late 2005, been on C, R and now two doses of Tysabri.

I've been off R for the most of the late summer and early fall until I had my first Ty in early October.

I've felt cruddy since about May/June when school got overwhelming and the heat and humidity started. I felt icky all summer long with depression, fatigue, constant daily fevers, and the problems with the heat and humidity which made me a summer vampire. I also had problems with my arms, hands, and fingers with severe weakness and some pain.

School starts here in September and I just got worse. Cognitive issues where I'd just blank at the board and couldn't remember how to do stuff I know like a division problem. More fatigue, much worse depression, fevers still, and problems with the arms and fingers.

So I just had a new MRI done to compare it to May 2008's MRI, and great news, I have a decrease in brain plaques!

So why do I feel so cruddy? I am out on a paid medical leave and now I feel like I should be doing much better due to what the MRI says.

I have one lesion in my spine that has been there since 2005 so I don't think it's anything going on in my spine.

Can someone brilliant come along and make sense of this for me? Why aren't I doing better with fewer lesions?

Help me to feel good about this and my leave, please!!

Thanks,
Weebs