Thanks for the replies. I do take two ADs, Lexapro and Abilify in the morning along with Provigil for alertness and Xanax for anxiety. The two ADs together are bringing me out of my depression.

I am out of work for now through Feb 1st, officially starting my leave on Tuesday of this week. I have been out of the classroom for the three weeks prior but still grading and planning and driving stuff back and forth at 6:30 in the morning.

I have had two Tysabri infusions, the most recent being last week. I just felt that if there are fewer lesions then I should be doing better and not the other way around. Maybe I just need to give it more time.

Thanks again for the replies,
Weebs

I'm really glad you are going to get a break, and that you will have a few more months of evaluating Tysabri before you have to make any short or long-term decisions. No matter what, the break will do you good.

Enhancing lesions and relapses are far from the end-all, be-all of this disease . . . although that is not what the "efficacy measures" for our drug options seem to imply. Several years ago (before Tysabri) they did regularly cycled MRI studies, and found that we would often have enhancing lesions with no symptoms/relapse, and no apparent lesions with plenty of disease activity going on.

They are still learning how all this ties together . . .

Cherie

hey weebs,
great big hugsssssssssss
hugss and more hugsssss

sorry you feeling blahhhhh, not sure on the MRI results compared to how you feel. I am undx, feel it migh be MS but MRI I am told are clear....with lots and lots of sxs of MS or something going on.

hugssss and hoping the break helps..if I had a break it might help for sure....hugss,sarah

opps didnt mean to make that all big...hehe just the huggg hehe

Weebs,
Let the Ty work for awhile before giving up...as an undxd with many MS sxs, it's frustrating to feel crummy while not having a dx. I'm sure you are frustrated that you're not improving...
Even though you have fewer active lesions, your body can still act up...
good luck, and I hope you feel some relief soon...