That's what I've been told too and read here. Wonder why dr wrote morning. I'll call tomorrow.

Eddie, if the doctor looked up Naltrexone 50 mg plus, a day, for alcohol and drug addiction, I would say they take that in the morning. It is not the same as Low Dose Naltrexone. He might have made that mistake in time that way.

LDN has a different purpose, it works at night.

If I take it too early, and don't get to bed, I get a sick tummy feeling, like I should be sleeping to get rid of that feeling.

Good luck Eddie with you LDN.

Well I still didnt get to call Dr to ask time to take it so I took it last night 15min before shut eye = 12am.
Woke up at 4:30 and maybe slept 1hr from 4:30 - 7:00 on/off in spirts.
Taking it tomorrow morn after shower!

You should continue to take it at night!

LDN has virtually no side effects. Occasionally, during the first week's use of LDN, patients may complain of some difficulty sleeping. This rarely persists after the first week. Should it do so, dosage can be reduced from 4.5mg to 3mg nightly.

What is the best dosage of LDN to begin treatment with?
For an adult who is not significantly below the normal weight range, the optimal dose of LDN is 4.5mg, taken each night at bedtime; i.e., between 9pm and 3am. One can begin at this dose level. If one were to develop persistent sleep disturbance (i.e., a sleep disturbance lasting longer than 10 to 14 days) after starting LDN, which occurs in less than 2% of users, then the dose may be decreased to 3mg or 2mg.
People who have multiple sclerosis that has led to muscle spasms are advised to begin treatment with just 3mg daily and to maintain that dosage.

If I have to work on a night shift, for example from midnight to 8a.m., at what time should I take my LDN?
Continue to take LDN as recommended above; i.e., between 9pm and 3am. This relates to the fact that the endorphins for each day are always produced in the pre-dawn hours, regardless of the hours when one is awake or sleeping.

all the above information is taken from www.lowdosenaltrexone.org

ExAcTlY!!!!!

I'll listen to you's since I agree and know thats when the brain says "make some". I'll take something with it to sleep. Thanks again.
Question - does it effect bowel movement in ANY way? I have hard to manage revised once colostomy. Constipation is no good, loose is a pain to manage.
Thanks

Eddie, I have an auto-immune bowel disease and somehow it went away. The Gastro doc is amazed. I could have either loose or a struggle, and now it is no problem.

Some take LDN for Crohn's disease, so I hope you don't have any problem with it. No one here has mentioned any negative effects in the plumbing, both B & B. Good luck.

Thanks Lady and thats great news for you!
I'm happy to report side effect I had (slight sleeplessness) is just about gone after 3 days. Great! I seem to wake up more thirsty then usual which is no problem. I always have bottled water ready to go bedside for tv watching. Anyone else get slightly thirsty?

Ok so after about 1 week of LDN, I notice nothing. Actually I dont even know what to expect. Numbness/tingles supposed to fade a little or at least stop increasing?

I've been out of here for a long time... but just wanted to get back to my fellow LDNers....

I'm a little disappointed in how LDN is going for me.

It seems like it has been a "wonder drug" for so many, and I naively thought that if I started it early in the disease I'd just nip it in the bud. But here I am--2 months into it, and I have a relapse of numbness in the trunk that lasts a few weeks.

Now, 8 months into it, I have increasing sx--my urinary frequency is going up, and I am having the MS hug into my chest. I feel like my lungs are being squeezed and I'm having asthma but albuterol doesn't do a thing. Still waiting to see the neuro, but I'm guessing it's the "hug".

If this is how I am a few months in LDN, I shudder to think what the hell is going to happen to me over years with this disease. LDN was my biggest hope. These days I'm pinning my hope on CCSVI, but who knows if I'll even get a chance to bat at that one.

Any advice? Thanks in advance, all!