But you can have imuran with MTHFR correct? I know my metabolism test they did for Imuran (can't remember the name specifically, i'm sure it's the one listed above).. was normal.. just wanted to make sure MTHFR doesn't interfere with this!! as that would be the drug we will step up to if need be..

I don't really know.... but that link I did put up mentioned a methyltransferase involved in Imuran metabolism. The MTHFR involves the reductase enzyme, which methylates folic acid and B12. I don't know if the same gene works for both.

The fine points of the DNA testing really should be evaluated by an expert in this. You can ask questions at the MTHFR.net website... he might know.

If you had the Imuran DNA screening test and it was normal, I'd think that would answer the question.

Thank you MrsD that makes it clear. As for the MTHFR mutation I only know what I have read here so can add little to previous answers thank you for your patience GrannyJo4

Though I did find this

Thiopurine methyltransferase (TPMT) is the main enzyme responsible for inactivating toxic products of azathioprine (AZA) metabolism. Patients with homozygous deficiency of this enzyme have no enzyme activity and ideally should not be given AZA. Patients with heterozygous deficiency have 50% of enzyme activity and have been shown to respond well and tolerate half a standard dose. If you do not have TMPT activity the a genetic screening should be carried out.


John