For me it started in the beginning of 2009, so 4 years already. It got worse and worse, because I didn't use any immunosuppressants or anything. However, I have been on those since 2010.

But now my question is this: my MG is now like it was in 2010, it's quite severe and does seem like I need respiratory support soon. I'm already back in the wheelchair fulltime, and cannot eat or drink.

But I wonder, I still use prednisone and others, but this worsening started since I lowered the prednisone.

Is this worsening because of the "natural" progressivity of the disease, like it gets worse the few 5 years or so? So it's kind of logical to have the same amount of weakness when I had at the beginning when I didn't use any immunosuppressant?

Or is this because once you start prednisone, and you lower the dosage, MG gets a bit of room...like give him an inch and he’ll take a yard?

Because I just find it weird, that with over 30 pills a day more (including mestinon) the muscleweakness is the same as it was 2,5 years ago. How does this mechanism work?

PS those 30 extra's do help, so it's not like they make it worse.