Hi, Ron. Welcome.

Please ask your primary doctor to test you for a B12 deficiency. When you experience twitching in your hands and feet, it could be a B12 deficiency.

It could also be a circulatory issue, but that's not as likely.

Because you're on Prednisone, you might have a calcium or Vitamin D deficiency, and those two things can cause twitching.

Also, if you are retaining fluids on Pred, that can give you an imbalance of electrolytes as well.

A high school friend of mine died of ALS. It's scary because most people die of it. They are finding different forms of ALS, some that are faster and some that aren't. There are usually other reasons for muscle twitches of fasciculations.

Ditto on what Limpy said.

Annie

I have had muscle twitches for almost 8 years - years before I had any symptoms.. They did get quite a bit worse when my symptoms initially flared 3 years ago.. the dr's never even bat an eye when I mention the twitches - they say everyone twitches... I do twitch worse when IVIG is wearing off.. i'm so used to it know though!

Thanks I cut the Mestinon to 60 mg 3 times per day and it seems to help. I am not twitching very much now.
Thanks for the replies

Ron:

Yay, Ron!!

Yep, I'd make a HORRIBLE doctor. "When you hear hoof beats, think horses, not zebras!" Zebras ALL the time for me. ;)

As a favor for others who may stumble upon this, the twitching and ALS connection is blown way out of proportion. Muscle fasciculation usually doesn't develop until someone is well aware they have ALS. Additionally, ALS twitches would be picked up on a needle EMG before they were even noticeable to you.