Hi Jana,

Its not everyday I get called a genius but I will take that lol!

I've known since the age of 15 about the stomach paralysis as I had a very good Gp when I started suffering from hemiplegic migraines ( I also get classic migraines) I only tend to vomit with my hemiplegic ones and as I tend to wake up in the night with them I get no warning. My current gp has given me suppositories now to use during an attack, anti sickness and two pain killers as I can't keep anything down. So maybe you could look into that Jana for your migraines?

Rach x

Great discussion, guys.

Limpy, When you mentioned the numbness and tingling, as did others, that's why I started this thread. So many people are B12 deficient and don't even know it. And it's uniquely important to MGers since we need B12 to make acetylcholine. I hope you will get tested, but, as Mrs D said, you need to be off of B12 for a while beforehand.

Yeah, Rach is a boffin from way back. ;) And her situation is an example of how much can go wrong when the autonomic nervous system is out of whack. She has POTS, and that can affect other systems in the body.

Jana, What is ironic is that both not enough and too much acetylcholine might trigger a migraine. I don't have migraines anymore. I took the triggers out of my diet (MSG, as in tomatoes which are a nightshade), stay away from bright lights, and now I have enough acetylcholine. Migraines run in my family and I honestly believe that they are related to some unknown genetic channelopathy. You could try taking some chewable calcium the next time you have a migraine. Benadryl might work, too, but not if you're sensitive to it, as some MGers are!!

The point I was trying to make is that in our little biochemical factory called the body, one little kink—no matter how seemingly insignificant—can throw the rest of the cogs off. This is how disease states begin.

Years ago, I did a bunch of research for a friend of mine with chronic migraines. Acetylcholine does play a role in them, as can other neurotransmitters. Why do you think they now recommend Botox for migraines? :cool:

This is a complex topic, because the biochemical processes in the body are all interrelated.

Below are some pearls that relate to MG and are interesting to contemplate. I don't have the energy right now to do a bunch of research. The thread I put up a while ago about this might still be here. Found it.

http://neurotalk.psychcentral.com/sh...d.php?t=182507

Migraines and neurotransmitters.

If you want to know more about migraines, simply google "migraines acetylcholine."

Scroll up to see the start of the chapter.

http://books.google.com/books?id=X4l...holine&f=false

The neurotransmitters and more.

http://www.moodocean.co.uk/html/neurotransmitters.html

http://umm.edu/health/medical/report...aine-headaches

Channelopathies

MG is a channelopathy.

http://www.bmj.com/rapid-response/20...hannelopathies

http://www.pps.org.pk/PJP/6-1/Amina.pdf

http://brain.oxfordjournals.org/content/125/6/1177.long

http://link.springer.com/article/10.....01.007#page-1

Paper based on studies about CFS being a neurological channelopathy.

http://phoenixrising.me/research-2/t...syndrome-mecfs

Antacids, acid blockers and acid inhibitors can be very destructive. They not only cause deficiencies in B12, iron, calcium and protein, but a host of other problems.

Food doesn't digest well enough.
Nutrients aren't absorbed into your small intestines as much.
Undigested food sits in the large intestines, putrefying and rotting.
That can lead to a leaky gut and loads of immune problems.
Bad bacteria builds up, overcrowding the good bacteria.
Infections (sinus, too) are easier to catch and harder to cure.
Immune complexes begin to multiply, attempting to fix you.
After that, you can have all sorts of problems, such as allergies, diseases, even more digestive problems, etc.

And inflammation. Inflammation can lead to infections can lead to cancer.

One thing leads to another. Get your B12 and D checked. ;)

Thank you Annie.

My nickname at university was boffin!

Its nice to be back on the forum its been a while!

Rach x

Ok.. so interesting day for me today, I had a colonoscopy/endoscopy - yay fun- for suspicion of crohns...I had bad GI symptoms with massive weight loss months before I ever had any neuro issues... (3 years ago).. was also breastfeeding through out this (not smart, I know now).. anyhow once the neuro symptoms started and I had IVIG my GI symptoms were also improved, but come back a bit when IVIG wears off.. until a couple of weeks ago things worsened, that with a family history of crohns made them think I might have that


ANyhow - on the topic of vitamin deficiencies- they ran a slew of lab tests - and they think I have malabsorption as I was very low in a few- Zinc, Folate, b1, B12, B6 and I think one more... My WBC was low (3.4), and my blood counts - which isn't suprising as I was having some bleeding - they have always been normal in the past.. Sounds like they are going to have me do B12 injections and sublinguals..

I had my b12 and mma drawn yesterday. I am hoping my loss of feeling in my hands is due to B12 and not some other malady. At least it can be treated.

Hi,
I found a great blog on vitamin B12 deficiency
www.b12deficiencyblog.WordPress.com
www.b12deficiency.info

Hope that address works let me know if it doesn't

Rach x