Myasthenia Gravis For support and discussions on Myasthenia Gravis, Congenital Myasthenic Syndromes and LEMS.

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Old 06-17-2007, 09:25 AM #1
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Default Cytoxan for MG?

Has anyone heard of docs using cytosan(anti-cancer drug) for MG?
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Old 06-17-2007, 06:17 PM #2
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I hadn't heard of it, but googled Cytoxan Myasthenia gravis, and found the following: Your doctor may also prescribe other medications that alter your immune system, such as azathioprine (Imuran), mycophenolate mofetil (CellCept), cyclophosphamide (Cytoxan) or cyclosporine (Sandimmune, Neoral). The site was http://www.cnn.com/HEALTH/library/DS/00375.html
and the info was toward the bottom of the page. Apparently it is fairly common. Good question. Are they planning on prescribing that for you?
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Old 06-17-2007, 10:43 PM #3
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Yes. If you Google, Myasthenia + Cytoxan there are loads of articles. It is usually used for more severe myasthenia and patients refractory to other meds.
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Old 06-18-2007, 06:56 AM #4
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Yes, Google "Revimmune + myasthenia." This is a very new and exciting treatment (Revimmune). Cytoxan is a cancer drug used in high doses to "reboot" the immune system. This drug has been developed to treat all autoimmune disease. Google "Rebooting Times HiCy" for a wonderful blog detailing an MS patient's experience with this protocol.
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Old 06-20-2007, 11:56 PM #5
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Note Immune Rebooting

Yes, high-dose cytoxan is used for the 'immune reboot' protocol that was developed Dr. Drachman and Dr. Brodsky (Johns Hopkins U). AngieB on this forum has gone through the treatment and I may be another one! I just received word from Dr. Drachman's office today that they're ready to set up my first consult. I am sooo excited!

Giving Myasthenia Gravis the (Re)Boot (Dr. Drachman and the protocol)

On the Trail of a Cure (A history of Dr. Brodsky and the protocol)

As Dr. Drachman stated at the MGFA 2007 conference, rebooting for myasthenics remains a treatment for refractory patients for now.

Jennifer in ON
Dx in 1986
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Old 09-11-2007, 04:08 PM #6
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Default High dose Cytoxan

I am a patient of Dr, Drachman. I have been for over three years for MG. After being denied Cytoxan treatment previously. He yesterday gave me the go ahead. I will more than likely get my start date by early next week. He has to run it by DR. Brodsky who is the Oncologist in the study and who is the money man for the Pharmaceutical company. I will keep you all posted.
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Old 09-17-2007, 10:44 AM #7
Janet Kelley Janet Kelley is offline
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Default Cylosporine

I haven't heard of cytoxan, but my husband has been taking cyclosporine for about 6 months now. Pretty nasty stuff!
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Old 10-07-2007, 10:37 PM #8
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Post Dr. Drachman..

Dear notwhatIordered:

I saw Dr. Drachman in August and he originally thought that I'd be a candidate for the reboot but I'm not. Simply because I have not exhausted all the immunosuppressant possibilities available. After 5 years, CellCept was not doing the trick. He's switched me to prograf. I continue to take prednisone daily (for the past 5 years, too).

I see Dr. D. again in February.

I've had MG since 1986 but went into a relapse in 2001 due to stress at work. For about 15 years, my symptoms were controlled with varying doses of mestinon. Then, when the relapse hit, I was started on prednisone, ivig, cellcept and a few other meds to control the side-effects of the MG drugs. Fun, eh?

Jennifer in St. Catharines, ON
36 yrs old and 4 years on LTD
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Old 10-10-2007, 06:36 AM #9
Ted Poole Ted Poole is offline
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Default MG

I have had MG for 3 years and have already used Cellcept, Imuran and Cyclosporine all didn't work. The cyclosporine was starting to damage
my kidneys so I just stoped taking it a couple of weeks ago. I also had
Plasma Pherisis and IVIG infusions. Iam still taking prednsone which had
given me glaucoma and cateracs and had to have both lenses replaced
on my eyes. It also has given me Barrets disease, Diabeties and High blood pressure. I also am on Mestinon.
Is Cytoxan the same as Cyclosporine?

Ted Poole
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Old 10-11-2007, 07:46 AM #10
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No, Cytoxan was originally developed as a cancer drug. When used to "reboot" the immune system it's called Revimmune or high dose cytoxan theraphy.
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