When I was first diagnosed with MG with exacerbated ocular/bulbar symptoms four years ago, I had no leg or arm weakness at all. After four years of prednisone, first at high doses but now at a reasonable 22.5 on alternating days, I feel like I'm walking through 4 ft. of water. By 9 PM I'm walking around like an 85 year old (I'm 65). I'm a photographer and have heavier than normal cameras and lenses but four years ago that was no problem. Now if I hold a camera up to my eye for awhile or do a long photo shoot, my arms get weak and achy and I just have to stop. If I squat, I have to use my hands to push myself back up. have no idea what's going on. I try to look on the bright side. Four years ago I had trouble speaking and swallowing and at times even breathing. Those things are basically under control now. Anyway those are my comments.

I too have all over fatigue with my myasthenia my neurologist says it is a symptom of myasthenia some mornings i feel exhausted before i even get up! Sometimes my all over fatigue is just when i have been over doing it but i do feel like it several times a day and need to rest.