Has anyone had that?

I had increasing stiffness in my hands and then, boom, over a span of a few days I got trigger finger in three of my fingers and one thumb (two in each hand).

It's not as though I do a lot with my hands, either!

A steroid injection helped the thumb, and I'll have another one in the worst finger.

It's kept me off of the computer for quite a while, so I apologize for that.

I really hope this isn't a sign of increasing inflammation! I'm glad I have some use of my hands back! Not a fun thing to have your fingers snap into a 90 degree angle! Thankfully, we have one of the best orthopedic clinics around here and they've been great!

Annie

Hi Annie

Are you taking Mention? If so I've experience if you overdose or take excessive amounts you tend to have this symptom or jolts and serious cramping in your feet, hands and leg muscles and it can be painful and bothersome, I use to get more when I was on higher doses, I use to take1080mg per day or 6x 180mg/every 4h, I'm now down to 330mg/day and experiencing less triggering, twitching and cramps...

Hi Snoel,
You probably held the world record with your previous Mestinon dosage. How did you come with such a huge amount of 1080 mg Mestinon per day?
Maurice.

Snoel, No, it's not an adverse reaction to Mestinon. Trigger finger is caused by an inflammatory process, which itself has many causes.

Frequency in Mestinon dosing, with a smaller dose (90 - 110 mg), is often a better way to go. Instead of every 4 hours, every 2-1/2 to 3 hours is common. But, of course, talk to your neuro first before making any changes.

You're basically flooding your neuromuscular junction with too much acetylcholine. I'm surprised you haven't had a cholinergic crisis by now.

Annie

I had 2 crises episodes in 2 months. Hospital Nuro put me on 1-1/2 or 2-60 mg Mestinon every 2 hours fron 6 in the morning until 6 at night. Then 1 Timespan at 9 pm. Also Predisone 20 mg and Imuran 100 mg. So far ok. Hoping for the best.
FREDH

I've reduce intake by a lot, when I took 1080mg/day I was in my worse state of my crisis...I'm now down to 240mg and 1x SR at bedtime and slowly diminishing my daytime dosage as I keep progressing...

I am sharing the record with you... 6 x 180mg, every 4 hours day and night.

Effects are wearing off again.