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Old 11-18-2018, 07:46 AM #1
Desha83 Desha83 is offline
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Default Confused about antibody

Hi! I wasnít sure where to post as my question is odd. My symptoms do not go along with MG. My biggest complaints are muscle spasms, muscle jerks, cramps and stiffness. I had the autoimmune panel ran and all of my AcHr antibodies are negative except for the striational antibody. I google and it continues to bring me to MG, but I donít think that antibody in isolation, along with my symptoms, points to MG. Do any of you have experience or knowledge about why this antibody could be elevated by itself?

I had a ct scan on Friday, hoping for results Monday. And I have an emg scheduled for a Tuesday.
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AnnieB3 (11-19-2018)
Old 11-18-2018, 02:57 PM #2
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Hi Desha83

Welcome to NeuroTalk .

My understanding is that striational antibodies can also be present at high levels in people with thymoma as well as in people with MG. The patterns of autoantibodies (striational, AChR and MuSK) can be very complicated in people with MG.

I hope that members with personal experience of MG will be able to provide you with more details about this.

Best wishes.
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Old 11-19-2018, 03:13 AM #3
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Hi, Desha83. Did you have the MuSK antibodies? Or the newest, LRP4? Antibody levels can fluctuate over time, and a good neuro will retest patients in 3 - 6 months.

The anti-striational antibodies can be from a number of things. Yes, MG is at the top of that list.

Striational antibodies in a paraneoplastic context. - PubMed - NCBI
Striated Muscle Antibodies, IgG with Reflex to Titer
Striational Antibodies in Myasthenia Gravis: Reactivity and Possible Clinical Significance | Cardiothoracic Surgery | JAMA Neurology | JAMA Network

Do you think your muscles are weak? Do you have ptosis (droopy eyelids)? Have you taken photos of your face to see for sure if they are dropping? Are you short of breath? Do you have trouble going up stairs? Do you have trouble using your arms?

When muscles become weak, they can cramp or spasm. In MG, they just do that sooner than "normal" people. Runners and other athletes do experience those symptoms after engaging in their sports. Our symptoms just occur sooner.

I have no way of knowing if you have MG. Be patient! I'm sure the doctors will figure this out one way or another.

If someone hasn't run a basic metabolic panel, they should. Anyone with muscle cramps should have their electrolytes and fluid balance looked at.

You could also have more than one thing going on at a time. Have you had your vitamin B12 and D checked? What about your thyroid?

Don't worry. Whatever is going on, the doctors sound like they are doing what they should to figure this out. Well, except for the other MG blood tests.

Do you have any other questions?

Just don't do too much, in case you do have MG. If you become worse, there's always the hospital! Take it easy.

Annie
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