I almost tried it a few months back. However, after I learned about the possibility of getting PML (activation of the JC virus with subsequent demyelination and death) since I also use Cellcept, I decided it just wasn't worth the risk for the possibility of the modest positive effects it may offer.

From what I understand, rituxan really doesn't show much effectiveness unless the patient has MuSK positive MG. In those patients, it seems that the longest remission ever achieved was between 1-2 years and something as simple as a viral infection can send you back to square one. In fact, the next clinical trial will be only using MuSK positive patients.

Good luck to your husband. Hope he is MuSK positive and has a great improvement.

Missy