Neuromuscular In memory of Rose Marie.


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Old 02-03-2009, 09:39 AM #1
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Default Increased risk of MSA and low cholesterol and HDL

Serum cholesterol levels and the risk of multiple system atrophy: A case-control study

Phil Hyu Lee, MD, PhD 1, Tae Sung Lim, MD 2, Hae-Won Shin, MD 3, Seok Woo Yong, MD 2, Hyo Suk Nam, MD 1, Young H. Sohn, MD, PhD 1 *

Funded by:
Stem Cell Research Center of the 21st Century Frontier Research Program; Grant Number: SC-4111


Cholesterol in brain membranes may modulate the conformational state and accumulation of -synuclein in -synucleinopathies.We examined the association between serum cholesterol and the risk of multiple system atrophy (MSA), one of the -synucleinopathies. We enrolled 142 patients with probable MSA from two tertiary referral hospitals and 155 age- and gender-matched healthy people with no neurological disease. The levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were significantly lower in MSA patients than in controls (total cholesterol: 172.7 vs. 196.3 mg/dL, P < 0.001; LDL-C: 104.0 vs. 115.3 mg/dL, P = 0.001; HDL-C: 47.3 vs. 54.2 mg/dL, P < 0.001). After adjusting for age, gender, use of cholesterol-lowering drugs, and histories of hypertension, diabetes mellitus, and smoking, the odds ratios was 5.9 (95% CI = 2.3-11.5, P < 0.001) for MSA patients in the lowest quartile of total cholesterol and 2.6 (95% CI = 1.2-5.5, P = 0.016) for those in the lowest quartile of HDL-C, compared with the highest quartiles. Levels of serum cholesterol did not significantly correlate with disease duration or severity. Our data suggest that lower levels of total cholesterol and HDL may be associated with an increased risk of MSA. © 2009 Movement Disorder Society
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Received: 13 October 2008; Revised: 8 December 2008; Accepted: 21 December 2008
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