I have one simple question that I can't get my doctors to answer one way or the other. Quick back ground info: (1) was on 60 mg Pred for 5 months, then started going down. Got to 17.5 and double vision came back. Went back to 20mg. daily (2) added CellCept 2000 mg/day in January 2010 (3) added Mestinon in April and double vision disappeared completely (4) a little over a month ago my legs (from hip to knee) started feeling like they were full of lead. They were weak and heavy to lift. I asked the drs. if this was due to MG or the 40 lbs I had gained on Pred, etc. GOT NO DIRECT ANSWER. SO, I am asking all of you - HAVE YOU EXPERIENCED THIS "LEAD LEG" FEELING? If so, what has your dr. said or what have you done about it? Three weeks ago I was reduced to 10 mg. of Pred and today I began reducing the CellCept in half since my vision is better. All by drs orders, of course. Last night my upper legs were so heavy I didn't think I was going to be able to get out of the chair and my left knee throbbed all night. I just wish they would tell me what is causingit. When I mentioned it was listed as a side effect of CellCept the dr. just shook his head back and forth as if to say "no". If it is because I have gained weight - just tell me. If it is something that just goes along with MG - just tell me (although they have told me I have "only ocular MG). I just want an answer. Hope someone out there can give me some info to ease my mind. My emotions are already all over everywhere from coming down on the Pred dosage, I can't add anymore stress! Thank you.: