I'm looking for suggestions.

My husband was diagnosed with Parkinson Disease in 2005, however his symptons are not typical. The neurologists are baffled.(He's seen 4) For two years he's been tested, scanned. MRI'ed etc. and tried on a host of medications. No one has a clue what accounts for his condition.

He has no tremor, no pain, no dementia. He has extreme weakness and constant fatique which is not helped with bed rest. The problem is not muscular, his musces are strong. Yet he can bafely support his own weight even with help of a walker. (He weighs 140 and is 5'6') He is currently on sinemet and though the result is less than expected, his symptons do worsen when taken off the drug. Other druge tried have not had favorable results. The head of Neurology says there is clearly something at work, other than the Parkinson, bu they can't find out what. Any suggestions on where to go from here? I'm nearly at my wts end!

welcome Barbara

I have also copied your post to our Parkinson's Forum as the members there are likely the best to try to answer your questions

here is the link to your post there
http://neurotalk.psychcentral.com/sh...ad.php?t=21019

Welcome, Barbara! I hope the good folks here can help you in your search for answers. It's hard, I know, and the frustration certainly does not help.

--ever been considered?

Has he had nerve conduction studies and/or electromyelography of his peripheral nerves, or any other tests for antibodies that are associated with motor neuropathies?

Sometimes, the assumption of one condition blinds medical professionals to the possibility of others--and many of us are "co-morbid".

Come on over to the peripheral neuropathy forum:

http://neurotalk.psychcentral.com/forumdisplay.php?f=20

and detail as much of the medical hisotry and tests as you are able; many very insightful people there.