Neuraltus Pharmaceuticals Reports Clinical Results from Phase 1/2 NP002 Study in the Treatment of Dyskinesias Resulting from Levodopa Therapy for Parkinson's Disease

http://www.prnewswire.com/news-relea...111255279.html

Abraham Lieberman, MD, the study's principal investigator and Director of the Muhammad Ali Parkinson's Center, commented, "NP002 represents an innovative approach to a common side effect in treating Parkinson's disease and has opened up new ideas on how to approach dyskinesias. The early study results of NP002 in patients with Parkinson's show promising trends in reducing dyskinesias and in improving gait. I am encouraged by these results and believe they provide a key piece in understanding and addressing the mechanism of dyskinesias in many of our patients with Parkinson's disease."

"NP002 is a small molecule, orally available nicotinic receptor agonist that has been shown in preclinical studies to reduce LIDs without affecting Parkinsonian symptoms."

This is a cholinergic medicine that is an agonist at the acetylcholine nicotinic receptor. It sounds to me like it would increase acetylcholine. Would someone who knows please correct me if I' m wrong...

It doesn't have to be a bad thing, but we are already over firing. So why would an excitatory drug help?

I am taking 40 mg of nortriptyline and 1.5 mg of xanax daily. low dosages of both and 2 amantadine. I am not dyskinetic unless stirred up, up late, something out of the ordinary, etc. i am much calmer now that i have given in to just spacing the meds out over the day so i'm taking something to even me out as i take sinemet every two hours. I get dyskinetic when i add any sort of dopmine agonists or comtan.