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Old 02-24-2011, 08:51 AM #1
CarolynS CarolynS is offline
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Join Date: Nov 2008
Location: Corning NY
Posts: 304
15 yr Member
CarolynS CarolynS is offline
Member
 
Join Date: Nov 2008
Location: Corning NY
Posts: 304
15 yr Member
Default Aav2-gdnf

Abstract available only.

Interventional MRI-guided Putaminal Delivery of AAV2-GDNF for a Planned Clinical Trial in Parkinson's Disease

Clinical trials involving direct infusion of neurotrophic therapies for Parkinson's disease (PD) have suffered from poor coverage of the putamen. The planned use of a novel interventional-magnetic resonance imaging (iMRI) targeting system for achieving precise, real-time convection-enhanced delivery in a planned clinical trial of adeno-associated virus serotype 2 (AAV2)-glial-derived neurotrophic factor (GDNF) in PD patients was modeled in nonhuman primates (NHP).


Prior GDNF - full history

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