Parkinson's Disease Clinical Trials For posting and discussion of clinical trials related to Parkinson's Disease, and for the Parkinson Pipeline Project. All are welcome.


advertisement
Reply
 
Thread Tools Display Modes
Old 03-27-2014, 09:24 PM #1
imark3000 imark3000 is offline
Member
 
Join Date: Nov 2007
Location: Calgary-Canada
Posts: 821
15 yr Member
imark3000 imark3000 is offline
Member
 
Join Date: Nov 2007
Location: Calgary-Canada
Posts: 821
15 yr Member
Default Role of Serotonin Neurons in L-DOPA- and Graft-Induced Dyskinesia in a Rat Model of P

Role of Serotonin Neurons in L-DOPA- and Graft-Induced Dyskinesia in a Rat Model of Parkinson's Disease:
http://www.hindawi.com/journals/pd/2012/370190/
Review Article
Role of Serotonin Neurons in L-DOPA- and Graft-Induced Dyskinesia in a Rat Model of Parkinson's Disease
Eunju Shin,1 Elisabetta Tronci,2 and Manolo Carta2
1Division of Neurobiology, Wallenberg Neuroscience Center, Lund University, 221 84 Lund, Sweden
2Department of Biomedical Science, Cagliari University, Cittadella Universitaria, SS 554 km 4.500, 09042 Monserrato, Italy

Received 16 February 2012; Revised 2 April 2012; Accepted 10 April 2012

Academic Editor: Gilberto Fisone

Copyright © 2012 Eunju Shin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

L-DOPA, the most effective drug to treat motor symptoms of Parkinson's disease, causes abnormal involuntary movements, limiting its use in advanced stages of the disease. An increasing body of evidence points to the serotonin system as a key player in the appearance of L-DOPA-induced dyskinesia (LID). In fact, exogenously administered L-DOPA can be taken up by serotonin neurons, converted to dopamine and released as a false transmitter, contributing to pulsatile stimulation of striatal dopamine receptors. Accordingly, destruction of serotonin fibers or silencing serotonin neurons by serotonin agonists could counteract LID in animal models. Recent clinical work has also shown that serotonin neurons are present in the caudate/putamen of patients grafted with embryonic ventral mesencephalic cells, producing intense serotonin hyperinnervation. These patients experience graft-induced dyskinesia (GID), a type of dyskinesia phenotypically similar to the one induced by L-DOPA but independent from its administration. Interestingly, the 5-HT1A receptor agonist buspirone has been shown to suppress GID in these patients, suggesting that serotonin neurons might be involved in the etiology of GID as for LID. In this paper we will discuss the experimental and clinical evidence supporting the involvement of the serotonin system in both LID and GID.
__________________
Imad
Born in 1943. Diagnosed with PD in 2006.
imark3000 is offline   Reply With QuoteReply With Quote

advertisement
Reply


Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Drug candidates for L dopa induced dyskinesia olsen Parkinson's Disease 0 09-22-2013 05:38 PM
parkinson's serotonin and dyskinesia aquario Parkinson's Disease 12 07-04-2010 02:10 AM
Levodopa Induced Dyskinesia? MikeTTF Parkinson's Disease 2 10-23-2009 03:16 PM
the gut, serotonin and intestinal neurons olsen Parkinson's Disease 2 08-08-2009 11:38 AM
Serotonin 1B receptor agonists may block l-dopa side effects ZucchiniFlower Parkinson's Disease 2 02-05-2008 10:02 AM


All times are GMT -5. The time now is 06:12 PM.

Powered by vBulletin • Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.