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09-11-2009, 10:21 PM | #1 | ||
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With a new clinical trial it brings up the question of how many PD patients have already tried Isradipine?
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09-12-2009, 04:29 AM | #2 | ||
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Junior Member
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Quote:
parkinsonsfocustoday.blogspot.com/ He has been on Isradipine since 2007 Good luck. If my forum does not allow me to post a URL -as I am a new member, Google search Parkinsonsfocustoday Kenki |
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09-12-2009, 11:46 AM | #3 | ||
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Junior Member
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Quote:
Who is Steve? He writes well and sounds like a conservative scientist. Robert |
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09-12-2009, 07:21 PM | #4 | |||
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Senior Member
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I've been on Isradipine since 2007 as well.
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Jean B This isn't the life I wished for, but it is the life I have. So I'm doing my best. |
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09-12-2009, 11:00 PM | #5 | ||
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09-13-2009, 09:39 AM | #6 | |||
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Senior Member
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Robert, I'm doing fine - no problems with dynacirc cr. (I've been taking it since Dr. Surmeir spoke at PAN a couple of years ago - 2007?) it controls my hypertension. of course i have no evidence of what it does for pd. BUT i have had spect scans in 2003-05-07-09 (from a different clinical trial) and I hope at some point that they can be sent to dr. surmeir for anecdocal data if nothing else.
i think my pd progression is slow - haven't had to adjust my meds in quite a while - nearly 2 years maybe. current meds: azilect, stalevo 100 3x, mirapex .25 3x, requip xl 3 tablets 1x, dynacirc cr 5mg 2x, lexapro 1.0 jean
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Jean B This isn't the life I wished for, but it is the life I have. So I'm doing my best. |
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09-13-2009, 10:32 PM | #7 | ||
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Junior Member
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Quote:
Robert |
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09-14-2009, 09:32 PM | #8 | |||
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Senior Member
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Robert,
I also exercise at least an hour a day - riding my trike, wii, swim ... Jean
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Jean B This isn't the life I wished for, but it is the life I have. So I'm doing my best. |
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09-15-2009, 09:43 AM | #9 | |||
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In Remembrance
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That this is a calcium channel blocker? In reading about ginger for the other thread, I found reference to it also being one. Interesting.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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09-15-2009, 09:46 AM | #10 | |||
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In Remembrance
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Not sure where to put this so I will do both but suggest that we discuss in the other one-
1: J Cardiovasc Pharmacol. 2005 Jan;45(1):74-80. Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. Ghayur MN, Gilani AH. Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi, Pakistan. Ginger (Zingiber officinale Roscoe), a well-known spice plant, has been used traditionally in a wide variety of ailments including hypertension. We report here the cardiovascular effects of ginger under controlled experimental conditions. The crude extract of ginger (Zo.Cr) induced a dose-dependent (0.3-3 mg/kg) fall in the arterial blood pressure of anesthetized rats. In guinea pig paired atria, Zo.Cr exhibited a cardiodepressant activity on the rate and force of spontaneous contractions. In rabbit thoracic aorta preparation, Zo.Cr relaxed the phenylephrine-induced vascular contraction at a dose 10 times higher than that required against K (80 mM)-induced contraction. Ca2+ channel-blocking (CCB) activity was confirmed when Zo.Cr shifted the Ca2+ dose-response curves to the right similar to the effect of verapamil. It also inhibited the phenylephrine (1 microM) control peaks in normal-Ca2+ and Ca2+-free solution, indicating that it acts at both the membrane-bound and the intracellular Ca2+ channels. When tested in endothelium-intact rat aorta, it again relaxed the K-induced contraction at a dose 14 times less than that required for relaxing the PE-induced contraction. The vasodilator effect of Zo.Cr was endothelium-independent because it was not blocked by L-NAME (0.1 mM) or atropine (1 microM) and also was reproduced in the endothelium-denuded preparations at the same dose range. These data indicate that the blood pressure-lowering effect of ginger is mediated through blockade of voltage-dependent calcium channels. PMID: 15613983 [PubMed - indexed for MEDLINE]
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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