http://brainwaves.corante.com/archiv...in_barrier.php

June 4, 2009
Future Neurotech Innovation: Crossing the blood brain barrier
Posted by Zack Lynch

Dozens of private companies are currently developing or commercializing neurodrug delivery methods and devices that will bring life to old and new compounds alike. These technologies include:
Implantable devices...
Expression systems: A French company is circumventing the BBB using encapsulated cell technology (ECT), a polymer implant containing cells that provide continuous, long-term release of the therapeutic protein to the brain or eye.
...Receptor-mediated transport: Receptors that transport nutrients
to the brain from the blood can be tricked into transporting therapeutic chemicals, peptides, and proteins across the BBB.
Cell-penetrating peptides: During the past decade, several arginine-rich peptides have been described, such as SynB vectors, which allow for intracellular delivery and BBB transport. The mechanism for this transport is unknown...
Focused ultrasound: Some research shows that focused ultrasound can temporarily open the BBB in a targeted area for a window of time. ..
Nanoparticle formulations: Nanoparticle formulations refer to
therapeutics encapsulated in nanoscale particles that can pass the BBB...