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01-06-2007, 07:16 PM | #1 | |||
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I was reading wikipedia.org, which is written collaboratively by people from all around the world so it's not always factual.
I read, "Dopamine agonists can also eventually contribute to Parkinson's disease symptoms by increasing the sensitivity of dopamine receptors" under the PD link. Any one ever heard that one before? I was always told by my neuro that some agonist "may be" neuroprotective. PD wiki link, it's under the Drug Induced section: http://en.wikipedia.org/wiki/Parkins...e_disturbances . . Robert
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01-06-2007, 07:44 PM | #2 | |||
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Seems it would allow one to get by with less dopamine, wouldn't it?
-Rick
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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01-07-2007, 12:04 AM | #3 | ||
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it also says levodopa can cause symptoms of pd - which, while i am not sure that that is inaccurate (have done some interesting reading on levodopa-induced apoptosis recently) i am not sure what feedback inhibition is.
people should really provide sources on wikipedia. i have never heard of DAs (or levodopa, i don't think) causing increased receptor sensitivity, nor have i ever heard of such a thing being responsible for pd symptoms - like rick said, it would seem to fly in the face of logic. boann |
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