FAQ/Help |
Calendar |
Search |
Today's Posts |
10-19-2009, 08:18 AM | #1 | |||
|
||||
In Remembrance
|
I know that RLSmi and others are using low dose dex as a protection, but has anyone tried it for dyskinesias?
1: Amino Acids. 1998;14(1-3):75-82. Blockade of glutamatergic transmission as treatment for dyskinesias and motor fluctuations in Parkinson's disease. Verhagen Metman L, Del Dotto P, Blanchet PJ, van den Munckhof P, Chase TN. National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland, USA. In animal models of Parkinson's disease (PD), glutamate antagonists diminish levodopa (LD)-associated motor fluctuations and dyskinesias. We sought to investigate if these preclinical observations can be extended to the human disease, by evaluating the effects of three non-competitive NMDA antagonists (dextrorphan, dextromethorphan and amantadine) on the motor response to LD in patients with advanced PD. In four separate trials, adjuvant therapy with these drugs reduced LD-induced dyskinesias and motor fluctuations. These findings support the view that drugs acting to inhibit glutamatergic transmission at the NMDA receptor can ameliorate LD associated motor response complications. PMID: 9871445 [PubMed - indexed for MEDLINE]
__________________
Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
|||
Reply With Quote |
|
|
Similar Threads | ||||
Thread | Forum | |||
Dextromethorphan by itself? | Peripheral Neuropathy | |||
Dextromethorphan/DM | Peripheral Neuropathy | |||
Dextromethorphan & Azliect | Parkinson's Disease | |||
Dextromethorphan redux | Parkinson's Disease | |||
Dextromethorphan | Medications & Treatments |