[reverett123]

You may have seen this already, but it won't hurt to post it again.


1. Neuropathol Appl Neurobiol. 2009 Apr;35(2):132-46. Epub 2008 Dec 11.

Review: Role of developmental inflammation and blood-brain barrier dysfunction in
neurodevelopmental and neurodegenerative diseases.

Stolp HB, Dziegielewska KM.

Department of Pharmacology, University of Melbourne, Parkville, Victoria,
Australia. hbstolp@unimelb.edu.au

The causes of most neurological disorders are not fully understood. Inflammation
and blood-brain barrier dysfunction appear to play major roles in the pathology
of these diseases. Inflammatory insults that occur during brain development may
have widespread effects later in life for a spectrum of neurological disorders.
In this review, a new hypothesis suggesting a mechanistic link between
inflammation and blood-brain barrier function (integrity), which is universally
important in both neurodevelopmental and neurodegenerative diseases, is proposed.
The role of inflammation and the blood-brain barrier will be discussed in
cerebral palsy, schizophrenia, Parkinson's disease, Alzheimer's disease and
multiple sclerosis, conditions where both inflammation and blood-brain barrier
dysfunction occur either during initiation and/or progression of the disease. We
suggest that breakdown of normal blood-brain barrier function resulting in a
short-lasting influx of blood-born molecules, in particular plasma proteins, may
cause local damage, such as reduction of brain white matter observed in some
newborn babies, but may also be the mechanism behind some neurodegenerative
diseases related to underlying brain damage and long-term changes in barrier
properties.

PMID: 19077110 [PubMed - indexed for MEDLINE]

[lurkingforacure]

this is great, and I am hoping they will do work on specific things and how each impacts the BBB....like vaccines, for example. Take a child, look at his BBB, give a vaccine, and look at the BBB after an hour, a day, a week, a month, a year...give a multi-vaccine (5-in-one) and same thing. they could do this with all sorts of things to see how each impacts the BBB.

We can't avoid everything that may impact the BBB negatively, though, so then I would think the question would be, how do we protect that BBB from those things we cannot avoid (crap in the air, stress, etc.).

[Ronhutton]

Hi Rick,
Well spotted. I had not seen this one, even though I have Google alerts on the BBB.
I have been in touch with other PD organisations on my "Role of the BBB in PD" paper, which I posted in 2006 here when Neurotalk began. I had posted earlier on the old Braintalk, but can't access those posts now.
What I would like to see is a measurement of the BBB permeability of PWP at various stages in PD, 1 year, 5 years 10 years etc. compared with healthy people. It can be done, I corresponded with a BBB expert who confirmed you can measure the permeability of living people. You could then try various drugs and supplements and observe the effect on BBB permeability. It would also be possible to find the value for the threshold permeability, above which you show PD symptoms.
Will we live to see it?? I am 73 now!!!
Ron

[pegleg]

Somehow I can go through the archived Wayback site and get into old BrainTalk forums.

See if you can access the BT forums from this link
http://web.archive.org/web/200206181...assCookie=true

And be patient; it takes a long time to load. This page happpens to be 2002. I'm not sure which d a te you were wanting.

Peggy

[Ronhutton]

Hi Peg,
Neuro Talk started I think around summer 2006, I know I joined in August 2006, shortly after the old Braintalk closed and Neurotalk started.
I can't be sure when I started at the old Braintalk, but I was trying to read my old posts on the BBB around 2003 to 2005.
Thanks for your URL, but I can't get to the above information from it. If I do any search, I just get "This page is not available" every time.
Many thanks anyway
Ron

[Ronhutton]

Two independent reports from Scandinavia say cell phones open the BBB
and allow toxins and proteins to enter the brain.

........ "diseases such as MS and Alzheimer’s are linked to proteins being found in the brain.
So, he added, is Parkinson’s Disease."
Ron
http://www.whole-life-insurance-quot.../12/14/23.html

Studying blood-brain barrier changes since the late 1980s, neurologist Leif Salford of Lund University in Sweden is the leading expert in this research. “With improved detection procedures and new tracers, one of his most recent studies found changes in the rat brain chemistry after only two minutes of cellphone-level exposures; the rats’ blood-brain barrier had failed, allowing proteins to enter the brain, and it is known that certain proteins which are normally present in blood, can cause nerve damage in the brain,” writes Aussie cellphone rsearcher and reporter Stewart Fist.

Professor Darius Leszcynski headed up the first two-year program looking at the effects of mobile phone radiation on human cells rather than those of rats at Finland’s Radiation and Nuclear Safety Authority. He, too found that cell phone transmissions open the blood-brain barrier to potentially brain-damaging toxins in the blood. [WSW July 11/02]

“We think we are on to something very significant,” Professor Salford says. “It seems that molecules such as proteins and toxins can pass out of the blood, while the phone is switched on, and enter the brain. We need to bear in mind diseases such as MS and Alzheimer’s are linked to proteins being found in the brain.”

So, he added, is Parkinson’s Disease. [Electronics Australia Magazine Feb/00]

[olsen]

Peg, thanks for the link to old brain talk forum. Are you aware of any way to obtain postings from 2004? thanks,madelyn

[mrsD]

sorry but from 3-04 thru 7-06.... those are truly gone.

Wayback archive links to the existing website...and that time period on BT is not available...totally gone! Unless you saved some.

[pegleg]

I have been fortunate to be able to access just about every year. There was one period (probably 2003-2004) that the server crashed and the forums were not backed up, so I beliewve that information was lost.

Tell me about when in 2004 (or what topic) and I'll try to find it. (Private message me if you like)
Peg