anticholinergic part 2

As only gathering facts - not a theory ....just questions and and inclination to find out exactly what is going on there. going to post facts as far as i can understand. it;s at NMDA receptors that I get lost but i usually get the drift eventually One knot in my stomach is designated to get to the bottom of cholinergic research. which is a line of words that all start with A... anyone agree A words all alike are assinine arggghhhh!

I can't resist giving this cholinergic dig a try, because it's where i am exactly and i have good friiends in the same place. but if any readers can see where I am in error or way behind or mistaken,, why would you [ understander of what i'm asking completely, who are open to what i am just grasping. ] - not speak up and set me straight? i don't venture too far into the biologic chemistry and it's not new thinking?

Drug developers are in a different mindset, many if them and researchers, cetainly big pharma , lobbyists , and even the president are taken in by the same wrong thinking , based on dollars. if we didn't have the stem cell breach that i am sure no one wants to talk about - because how divided this nation is - after listening to bush is stupid and how stupid anyone is to think embryos are people , etc ec for eight years now people freak out if you mention the administration when our health care and economy are at risk.

The future is in Europe.

we had best get it together and recognize
"the urgency of now" MLK

questions:

is this producing anything?
http://www.michaeljfox.org/research_...s_3.cfm?ID=454

also trying to understand this one its's over my head, altho it does mention blocking the excitatory effects of actetylcholine-not sure what that means - it is classified as a cholinesterase inhibitor-not what i see any evidence of pwp needing yet
http://www.pdonlineresearch.org/reso...ease-eliprodil

no results reported
http://clinicaltrials.gov/archive/NC...979/2008_03_03

i have found nothing on better anticholinergic drugs like artane yet they are saying pd dementia also is low in acetylcholine but why hasn't one person come into the forum and said that? we know that anticholinergic drugs make you cognitively out of it -like cogentin. . i understand that lowering acetylcholine causes cognition interference but where is the evidence that we are low in acetylocholine?

I'm not convinced these drugs are for pd
What defines pd dementia ? i am starting to dislike that term.

Can someone explain this study?

About Fipamezole

Fipamezole is an antagonist of the adrenergic alpha-2 receptor with a novel mode of action in the treatment of Dyskinesia in Parkinson's Disease. The rationale behind the development of fipamezole is to increase noradrenergic release in certain areas of the brain, resulting in rebalancing of the distorted brain network and potentially alleviating symptoms of advanced Parkinson's disease such as dyskinesia, motor fluctuations, orthostatic hypotension and cognitive impairment without exacerbating the underlying Parkinsonian features of the disease. In a recent Phase IIb study, Santhera demonstrated that JP-1730/fipamezole has the potential to reduce Dyskinesia in Parkinson's Disease with the study results also suggesting that the drug has the potential to reduce "off time" and improve cognitive function. Furthermore, the reduction in dyskinesia was found to be strongly correlated with the investigator's clinical global impression of improvement in overall condition.

http://clinicaltrials.gov/show/NCT00767091

thank you