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01-17-2010, 05:19 PM | #1 | |||
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In Remembrance
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And 1992 at that!
1. Neurosci Lett. 1992 Oct 12;145(2):175-7. Increased plasma concentrations of aspartate, glutamate and glycine in Parkinson's disease. Iwasaki Y, Ikeda K, Shiojima T, Kinoshita M. Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan. We measured fasting plasma amino acids in 20 patients with Parkinson's disease (PD) and 20 controls matched for age and sex. PD patients had significant elevations in plasma levels of aspartate, glutamate and glycine. The levels of other amino acids were not significantly different from those found in controls. No correlation was noted between PD severity and the degree of abnormality of plasma amino acids. We conclude that excitatory amino acids may be altered in patients with PD, and raise the possibility that neuroexcitotoxic mechanisms may be involved in the neurodegeneration of PD. PMID: 1361223 [PubMed - indexed for MEDLINE]
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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01-17-2010, 07:24 PM | #2 | ||
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In Remembrance
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this includes all of the transmitters and amino acids.
http://www.benbest.com/science/anatm...0.html#glycine I truly do not understand why other transmitters are not as focused upon. A google search [again with acetylcholne written everywhere]. http://www.google.com/search?q=does+...8&sourceid=ie7 http://en.wikipedia.org/wiki/Acetylcholine paula
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paula "Time is not neutral for those who have pd or for those who will get it." |
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"Thanks for this!" says: | Conductor71 (01-17-2010) |
01-17-2010, 08:15 PM | #3 | |||
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In Remembrance
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The amino acids in question are excitotoxic. Under the right circumstances they cause neurons to work so hard they die. MSG gets its bad reputation from that and aspartame sweetner as well.
If these are elevated in plasma, why so and what does it imply?
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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01-17-2010, 08:21 PM | #4 | ||
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In Remembrance
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Would they be elevated if acetylcholine was elevated?
p
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paula "Time is not neutral for those who have pd or for those who will get it." |
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01-17-2010, 09:53 PM | #5 | |||
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Laura |
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