[reverett123]

I know that this is a little absurd at first glance, but what if Sinemet and maybe even the agonists are not easing symptoms for the reasons everyone assumes but for another reason altogether.

I got to wondering about this when I came across a study which showed a dramatic temporary drop in cortisol when one takes Ldopa. Other studies show that PWP have high cortisol levels, so a drop might be welcome news while it lasted. And we all know that when the change is in the other direction, all hell breaks loose. Does it seem unreasonable that a drop would improve function?

Another thing I have wonderred about is that I can crawl to bed completely shot. The last med several hours in my past and the next one hours in my future. Yet, if I wake up in the night, I'm not surprised to find that I am in pretty good shape. And the degree of improvement is related to when I wake up, 1:00 AM is different than 5:00 AM. But if I stay up then it isn't long before symptoms start. I have used up the dopamine that accumulated while I slept. Or had I? What if the explanation was that my cortisol levels rose instead?

Worth a thought....