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06-27-2011, 03:14 AM | #6 | ||
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In addition to local factors and genetics, my hunch is that there is a climatological connection.
The Parkinson's distribution maps hint at a relationship between prevailing wind direction and PD. In itself this is not causal. However, one possible causal mechanism follows from the wind affecting surface ozone levels [1]. Especially in summer, these seem to be distributed in a similar way to PD. In turn, ozone levels affect nitric oxide levels in the body [2]. NO may be implicated in Parkinson's both directly [3] and indirectly, by increasing the permeability of the BBB [4]. Proper statistical analysis is required. [1] http://acdb-ext.gsfc.nasa.gov/Data_s...ce/gif/cl2.gif [Shows tropospheric ozone levels, not ground levels.] [2] http://www.ncbi.nlm.nih.gov/pubmed/17662977 [3] http://www.ncbi.nlm.nih.gov/pubmed/16005074 [4] http://www.liebertonline.com/doi/abs...08601300185223 John Last edited by johnt; 06-27-2011 at 04:13 AM. Reason: Typo |
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"Thanks for this!" says: | Conductor71 (06-27-2011), VICTORIALOU (06-28-2011) |
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