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Parkinson’s Progression Halted by Inhibiting Enzyme



Parkinson's Progression Halted by Inhibiting Enzyme - Neuroscience News


Summary: Researchers discovered that inhibiting a specific enzyme, USP30, in a mouse model protects dopamine-producing neurons, which are typically lost as the disease progresses.
This groundbreaking finding suggests a new therapeutic avenue that could slow or even prevent Parkinson’s progression.
The study involved both genetic and pharmacological methods to demonstrate the protective effects of USP30 inhibition on neuronal health and disease symptoms.
Key Facts:

1. The study showed that inhibiting the USP30 enzyme protected dopamine-producing neurons in a Parkinson’s mouse model.
2. Researchers used both genetic ‘knockout’ models and a proprietary molecule to block USP30, leading to increased clearance of damaged mitochondria.
3. These findings offer new hope for developing treatments that could potentially modify the course of Parkinson’s disease.