My Friend started Azilect on the 7th - last Sunday. From Monday his dykinesia has become worse.

We have tried to reduce the Sinemet - 25/100 made into a solution and drank twice within the same time window as the 25/100 dose, but it is of no use at that reduced level.

Before he used to find the mornings to be relatively free of symptoms, but now he wakes up feeling weakness in the legs - perhaps a seperate issue?

Is there anything else that can help with the dyskinesia? We tried Amantadine, but that did nothing. How long does one need to wait to see any effect while on it? He was on 100 mg for a week and then 200 mg for the next two.

It is a very confusing time. I really did think that the DXM was helping with the tremor as well as the dyskinesia, but now with the addition of Azilect we've had to discontinue that.

This is freaking scary.