Scutellaria baicalensis is the big brother to American skullcap. It has been on my "to test" list for a long time and I started yesterday. So this is very preliminary. But one thing has already surfaced - this stuff is an extremely effective anti-inflammatory and I have proven it more clearly than I expected. Let me explain-

I have a space between two of my molars that traps food. I have to keep at it constantly to keep it from getting very painful, i.e. inflamed. And because I am undisciplined the normal condition is sore to touch. Except that today there is no tenderness whatsoever. It has been well over a year since I have been like that. In truth I don't remember just when. Today I can poke it with my finger with no mercy and there is no pain.

I took a single capsule yesterday containing 200 mg of the root standardized to 34 mg baicalein and 0.8 mg wogonin. Brand "New Chapter".

I am not going to report on PD-related effects for a few days, but you might be interested in these reports:


1. J Neural Transm. 2005 Mar;112(3):331-47. Epub 2004 Oct 22.

Inhibition of microglial activation by the herbal flavonoid baicalein attenuates
inflammation-mediated degeneration of dopaminergic neurons.

Li FQ, Wang T, Pei Z, Liu B, Hong JS.

Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National
Institute of Environmental Health Sciences, Research Triangle Park, NC 27709,
USA.

Accumulating evidence has suggested that inflammation in the brain participates
in the pathogenesis of Parkinson's disease (PD). Therefore, anti-inflammatory
therapy has attracted much attention as novel interference to neurodegenerative
diseases. Baicalein, a major flavonoid extracted from a traditional Chinese herb
Scutellaria baicalensis Georgi (Huangqin), possesses potent anti-inflammatory and
antioxidant properties. To test the potential neuroprotective effect of baicalein
on dopaminergic neurons, primary midbrain neuron-glia cultures from E-14 rat
embryos were used. Cultures were pretreated with baicalein for 30 min prior to
stimulation with lipopolysaccharide (LPS, 10 ng/ml). LPS leads to massive
activation of microglial cells revealed by OX-42 immunostaining, and produced
excessive quantities of NO. Excessive elevation of superoxide level was also
observed in enriched-microglia after stimulating with LPS. LPS-induced damage to
dopaminergic neurons was evaluated by uptake capacity for [3H]dopamine and
tyrosine hydroxylase (TH)-immunocytochemistry. Pretreatment with baicalein
concentration-dependently attenuated LPS-induced decrease in [3H]dopamine uptake
and loss of TH-immunoreactive (TH-ir) neurons, which the maximum protective
effect was observed at the concentration of 5 microM. Post-treatment with
baicalein (5 microM) was also shown to be effective even if baicalein
administered up to 2 h later than LPS application. Morphological study shows that
baicalein (5 microM) almost completely blocked LPS-induced activation of
microglia. Excessive production of TNF(alpha) and free radicals such as NO and
superoxide by LPS stimulation were also attenuated by baicalein at a
concentration-dependent pattern. The present study indicates that baicalein
exerts potent neuroprotective effect on LPS-induced injury of dopaminergic
neurons. We hypothesize that the inhibition of LPS-induced production of NO and
free radicals from microglia may underlie the mechanism of baicalein's
neuroprotection.

PMID: 15503194 [PubMed - indexed for MEDLINE]


1. J Neural Transm. 2005 Mar;112(3):331-47. Epub 2004 Oct 22.

Inhibition of microglial activation by the herbal flavonoid baicalein attenuates
inflammation-mediated degeneration of dopaminergic neurons.

Li FQ, Wang T, Pei Z, Liu B, Hong JS.

Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National
Institute of Environmental Health Sciences, Research Triangle Park, NC 27709,
USA.

Accumulating evidence has suggested that inflammation in the brain participates
in the pathogenesis of Parkinson's disease (PD). Therefore, anti-inflammatory
therapy has attracted much attention as novel interference to neurodegenerative
diseases. Baicalein, a major flavonoid extracted from a traditional Chinese herb
Scutellaria baicalensis Georgi (Huangqin), possesses potent anti-inflammatory and
antioxidant properties. To test the potential neuroprotective effect of baicalein
on dopaminergic neurons, primary midbrain neuron-glia cultures from E-14 rat
embryos were used. Cultures were pretreated with baicalein for 30 min prior to
stimulation with lipopolysaccharide (LPS, 10 ng/ml). LPS leads to massive
activation of microglial cells revealed by OX-42 immunostaining, and produced
excessive quantities of NO. Excessive elevation of superoxide level was also
observed in enriched-microglia after stimulating with LPS. LPS-induced damage to
dopaminergic neurons was evaluated by uptake capacity for [3H]dopamine and
tyrosine hydroxylase (TH)-immunocytochemistry. Pretreatment with baicalein
concentration-dependently attenuated LPS-induced decrease in [3H]dopamine uptake
and loss of TH-immunoreactive (TH-ir) neurons, which the maximum protective
effect was observed at the concentration of 5 microM. Post-treatment with
baicalein (5 microM) was also shown to be effective even if baicalein
administered up to 2 h later than LPS application. Morphological study shows that
baicalein (5 microM) almost completely blocked LPS-induced activation of
microglia. Excessive production of TNF(alpha) and free radicals such as NO and
superoxide by LPS stimulation were also attenuated by baicalein at a
concentration-dependent pattern. The present study indicates that baicalein
exerts potent neuroprotective effect on LPS-induced injury of dopaminergic
neurons. We hypothesize that the inhibition of LPS-induced production of NO and
free radicals from microglia may underlie the mechanism of baicalein's
neuroprotection.

PMID: 15503194 [PubMed - indexed for MEDLINE]


1. Clin Mol Allergy. 2007 Nov 26;5:5.

Baicalein inhibits IL-1beta- and TNF-alpha-induced inflammatory cytokine
production from human mast cells via regulation of the NF-kappaB pathway.

Hsieh CJ, Hall K, Ha T, Li C, Krishnaswamy G, Chi DS.

Departments of Internal Medicine, James H, Quillen College of Medicine, East
Tennessee State University, Johnson City, Tennessee 37614, USA. chi@etsu.edu.

ABSTRACT: BACKGROUND: Human mast cells are multifunctional cells capable of a
wide variety of inflammatory responses. Baicalein (BAI), isolated from the
traditional Chinese herbal medicine Huangqin (Scutellaria baicalensis Georgi),
has been shown to have anti-inflammatory effects. We examined its effects and
mechanisms on the expression of inflammatory cytokines in an IL-1beta- and
TNF-alpha-activated human mast cell line, HMC-1. METHODS: HMC-1 cells were
stimulated either with IL-1beta (10 ng/ml) or TNF-alpha (100 U/ml) in the
presence or absence of BAI. We assessed the expression of IL-6, IL-8, and MCP-1
by ELISA and RT-PCR, NF-kappaB activation by electrophoretic mobility shift assay
(EMSA), and IkappaBalpha activation by Western blot. RESULTS: BAI (1.8 to 30 muM)
significantly inhibited production of IL-6, IL-8, and MCP-1 in a dose-dependent
manner in IL-1beta-activated HMC-1. BAI (30 muM) also significantly inhibited
production of IL-6, IL-8, and MCP-1 in TNF-alpha-activated HMC-1. Inhibitory
effects appear to involve the NF-kappaB pathway. BAI inhibited NF-kappaB
activation in IL-1beta- and TNF-alpha-activated HMC-1. Furthermore, BAI increased
cytoplasmic IkappaBalpha proteins in IL-1beta- and TNF-alpha-activated HMC-1.
CONCLUSION: Our results showed that BAI inhibited the production of inflammatory
cytokines through inhibition of NF-kappaB activation and IkappaBalpha
phosphorylation and degradation in human mast cells. This inhibitory effect of
BAI on the expression of inflammatory cytokines suggests its usefulness in the
development of novel anti-inflammatory therapies.

PMCID: PMC2206049
PMID: 18039391 [PubMed - in process]

Hi Reverett - I have been looking into this as well. I am not sure I can PM you - please PM me with your email and I can share many articles on skullcap. I am trying to figure out correct dosing and have spent quite a bit of time on this. I'd be curious as to your thoughts. Glad you had a positive initial reasction.

Hello. Email is in signature below. -Rick

Rick,

You have uncanny timing. I purchased some of the Chinese Skullcap by mistake (was actually wanting American) but was glad to have it on hand this morning when cold water hit what used to be a filling in my molar.
I wigged out for two reasons...I just read of Ron's ordeal with an abcessed tooth and my symptoms have been a bit wonky out the blue, so I am thinking that I have a little mercury in my system now which can't be good. Reason Two is that my dentist doesn't do weekends. I am pleased to report that I've only taken one dose and no pain in my tooth all day

Any advice on how to get that filling replaced? Can they do porcelain right over an old filling?

Laura

No, you want rid of that old stuff and new material on a clean base. Explain your concerns about infection. You may be surprised to find that he understands completely. Dentists know what hidden infections can do - they've seen it. If it is an upper it can dissolve bone all the way to the brain. Talk about passing the BBB!

She might also give you a chance to try acourse of antibiotics if you ask.

I sent away for the skullcap and will watch and report any findings. In the meantime, my knee went out (may or may not be PD related). Went to the dr and got a prescription for 800 mg Ibuprofen. It eased my knee pain but also seemed to really upset my PD medications. I take carbidopa/levo 25-100 every 4 hours pretty much round the clock along with comtan 200 with each dose. When I added the Ibuprofen, it seemed to amplify the effects of the PD meds and suddenly I had dyskinesia which I rarely experience otherwise. First reaction was that this was bad... second reaction was that this might be good and that I might try cutting down my PD meds because of the effects of the anti-inflamatory. So... for what it's worth, maybe anti-inflamatory meds hold a key.