Parkinson's Disease Tulip


advertisement
Reply
 
Thread Tools Display Modes
Old 02-04-2007, 11:06 AM #1
olsen's Avatar
olsen olsen is offline
Senior Member
 
Join Date: Aug 2006
Posts: 1,860
15 yr Member
olsen olsen is offline
Senior Member
olsen's Avatar
 
Join Date: Aug 2006
Posts: 1,860
15 yr Member
Default acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and ne

In my continual search for information concerning mitochondrial dysfunction and oxidative stress therapies, found the following:

Free Radic Biol Med. 2007 Feb 1;42(3):371-84. Epub 2006 Nov 10. Links
Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: Implications for Alzheimer's disease.Mohmmad Abdul H, Butterfield DA.

Oxidative stress has been shown to underlie neuropathological aspects of Alzheimer's disease (AD). 4-Hydroxy-2-nonenal (HNE) is a highly reactive product of lipid peroxidation of unsaturated lipids. HNE-induced oxidative toxicity is a well-described model of oxidative stress-induced neurodegeneration. GSH (glutathione) plays a key role in antioxidant defense, and HNE exposure causes an initial depletion of GSH that leads to gradual toxic accumulation of reactive oxygen species. In the current study, we investigated whether pretreatment of cortical neurons with acetyl-L-carnitine (ALCAR) and alpha-lipoic acid (LA) plays a protective role in cortical neuronal cells against HNE-mediated oxidative stress and neurotoxicity. Decreased cell survival of neurons treated with HNE correlated with increased protein oxidation (protein carbonyl, 3-nitrotyrosine) and lipid peroxidation (HNE) accumulation. Pretreatment of primary cortical neuronal cultures with ALCAR and LA significantly attenuated HNE-induced cytotoxicity, protein oxidation, lipid peroxidation, and apoptosis in a dose-dependent manner. Additionally, pretreatment of ALCAR and LA also led to elevated cellular GSH and heat shock protein (HSP) levels compared to untreated control cells. We have also determined that pretreatment of neurons with ALCAR and LA leads to the activation of phosphoinositol-3 kinase (PI3K), PKG, and ERK1/2 pathways, which play essential roles in neuronal cell survival. Thus, this study demonstrates a cross talk among the PI3K, PKG, and ERK1/2 pathways in cortical neuronal cultures that contributes to ALCAR and LA-mediated prosurvival signaling mechanisms. This evidence supports the pharmacological potential of cotreatment of ALCAR and LA in the management of neurodegenerative disorders associated with HNE-induced oxidative stress and neurotoxicity, including AD.

PMID: 17210450 [PubMed - in process]
__________________
In the last analysis, we see only what we are ready to see, what we have been taught to see. We eliminate and ignore everything that is not a part of our prejudices.

~ Jean-Martin Charcot


The future is already here — it's just not very evenly distributed. William Gibson
olsen is offline   Reply With QuoteReply With Quote

advertisement
Old 02-04-2007, 12:10 PM #2
reverett123's Avatar
reverett123 reverett123 is offline
In Remembrance
 
Join Date: Aug 2006
Posts: 3,772
15 yr Member
reverett123 reverett123 is offline
In Remembrance
reverett123's Avatar
 
Join Date: Aug 2006
Posts: 3,772
15 yr Member
Default big medicine

Acetyl-L-Carnitine and ALA both are among the best things we can take. There is a wealth of info on Medline. One especially heartening one (that I can't lay my hands on right now of course) showed ALCAR to actually increase the cross sectional area of the nerve fibers and improve diabetic neuropathy by making the remaining nerves more efficient.

Here is a general clip from 12 years ago! Makes you wonder why it isn't a standard part of out treatment doesn't it!

1: Life Sci. 1994;54(17):1205-14.

Acetyl-L-carnitine affects aged brain receptorial system in rodents.

Castorina M, Ferraris L.

Institute for Research on Senescence, Sigma-Tau, Pomezia, Rome, Italy.

Acetyl-L-carnitine (ALCAR), the acetyl ester of carnitine, is regarded as a
compound of considerable interest because of its capacity to counteract several
physiological and pathological modifications typical of brain ageing processes.
In particular, it has been demonstrated that ALCAR can counteract the
age-dependent reduction of several receptors in the central nervous system of
rodents, such as the NMDA receptorial system, the Nerve Growth Factor (NGF)
receptors, those of glucocorticoids, neurotransmitters and others, thereby
enhancing the efficiency of synaptic transmission, which is considerably slowed
down by ageing. The present review thus postulates the importance of ALCAR
administration in preserving and/or facilitating the functionality of
carnitines, the concentrations of which are diminished in the brain of old
animals.

PMID: 8164502 [PubMed - indexed for MEDLINE]
__________________
Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
reverett123 is offline   Reply With QuoteReply With Quote
Reply


Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Inflamation, Oxidative Stress lead to Neurodegeneration ashleyk Parkinson's Disease 1 12-29-2006 08:37 AM
GDNF reduces oxidative stress in a 6-hydroxydopamine model of Parkinson's disease. olsen Parkinson's Disease 1 12-06-2006 09:42 PM
stress, finding ways to reduce stress.... bizi Bipolar Disorder 2 09-17-2006 12:05 PM


All times are GMT -5. The time now is 06:08 PM.

Powered by vBulletin • Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.