Wow! 10 minutes!

I take it every 3 hours and around an hour of those 3 hours is kinda down time. and after 4 it's all down time, unless I sneak another one.

The correlation some of you have made between Sinemet and drug addiction rings more true the farther in I get.

I will do it eventually, but I've always thought it should be possible to draw individual bellcurves fpr each drug and superimpose or overlay them to work out the optimum dosing schedule for each individual.

It might be possible to take a Saturday morning and start the day with a typical dose of one single med. Note the time and then track the changes as the drug kicks in. Keep at it until completely gone and you are miserable again. When you feel better convert the data to a curve on graph paper. Note, in particular, when you took it, when you felt first effect, when you became alive, when you became dyskinetic, when you stopped, when you first noticed it wearing off, and when you crashed.

Make a half-dozen photocopies (one for each time you take one. Next weekend do it again for another med. Once you have a set of curves custom fitted to you, it should be possible to play with them to optimize your on time.

Ive had it kick in very late too, and sometimes not at all

Lately it has been about 30 mins to and hour on the average

My Stavelo kicks in around 45 minutes, it occasionally fails to kick in and i take a second dose. However, a "dose" for me is 25mg of levodopa!! Even that low level gives me raging dyskinesia. However, I can be on most of the day with only 125 to 175mg levodopa. I split a 50mg Stavelo.
I really can't say categorically what has made me so sensitive to levodopa after 19 years of PD. I think prolonged use of at least 1,000mg curcumin has helped a lot. As a white rat, I have tried many things, only to see little short term improvement, and given them up.
Has anyone else taken curcumin for a prolonged time, >5years?
Ron

K Ray Chaudhuri, Anthony HV Schapira. Non-motor symptoms of Parkinson’s disease: dopaminergic pathophysiology and treatment. Lancet Neurology, 2009; 8: 464–74

There are several commonly encountered subtypes of response fluctuations. (1) The "wearing off" phenonemon—this signifies shortening of the duration of clinical relief induced by the individual doses of levodopa. If at the initial phase each dose may work for several - 3-5 hours later, there is a gradual and progressive shrinkage to 1 to 2 hours lasting benefit. (2) The "delayed on" phenomenon—this signifies increased latency periods from intake of an oral dose of levodopa to start up of a clinical benefit.8 If, initially when the patient first becomes a fluctuator, such latency may have been brief and ranged from 5 to 20 min, there is now a gradual and progressive increase in its duration. Patients may sometimes have to wait for as long as 30 min to 11⁄2 hours for an onset of an "on" phase and clinical relief. (3) The "no-on" phenomenon—this signifies occasionaltotal failure of an oral dose of levodopa to induce an "on."9 Such episodic unresponsiveness is often described by the patients as if the unsuccessful dose of levodopa has not been taken at all. It is more common after food and in the afternoon. (4) The "on-off" phenomenon—although initially this term was used to generally describe all the subtypes of motor fluctuations, it currently refers particularly to abrupt and mostly random and unpredictable loss of benefit, which occurs during a successful "on" phase. This may be characterized by a severe parkinsonian crisis associated with sympathetic overactivity, e.g., palpitations, hot flushes, sweating, and panic. Such an attack may last from minutes to hours and may subside spontaneously or only after intake of an additional dose of levodopa,

disclaimer: we are all different but i am classic parkinson with rigidity but no tremor. They are different in how they respond to meds.

This one is important so let's move it to its own space.