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02-14-2014, 12:27 PM | #51 | ||
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Gentelmen see my latest post:
Parkinson’s disease patients exhibit progressive spreading of aggregated α-synuclein in the nervous system. This slow process follows a specific pattern in an inflamed tissue environment. Recent research suggests that prion-like mechanisms contribute to the propagation of α-synuclein pathology. Little is known about factors that might affect the prion-like behavior of misfolded α-synuclein. In this review, we suggest that neuroinflammation plays an important role. We discuss causes of inflammation in the olfactory bulb and gastrointestinal tract and how this may promote the initial misfolding and aggregation of α-synuclein, which might set in motion events that lead to Parkinson's disease neuropathology. We propose that neuroinflammation promotes the prion-like behavior of α-synuclein and that novel anti-inflammatory therapies targeting this mechanism could slow disease progression. |
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02-14-2014, 07:21 PM | #52 | ||
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Senior Member
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I have not found any research reconciling these conflicting findings. |
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02-14-2014, 07:52 PM | #53 | ||
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02-14-2014, 08:30 PM | #54 | ||
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Magnate
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Last edited by soccertese; 02-14-2014 at 08:36 PM. Reason: grammar |
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02-15-2014, 02:41 AM | #55 | ||
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Hello !
I scanned Dr Paneri's diet and put in Online All items with X ,are forbidden cheers |
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"Thanks for this!" says: | zanpar321 (02-15-2014) |
02-15-2014, 02:42 AM | #56 | ||
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02-15-2014, 02:48 AM | #57 | ||
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hello badboy !
what do you mean by adjust ? you have to increase your dose of nicotine every 2 months by 3,5 mg no more, no less . don't increase more than 3,5mg every 2 months ,to be effective ,it has to be STEP BY STEP. kind regards |
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02-15-2014, 12:37 PM | #58 | ||
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Hi Villiers! How do I know when I have arrived at my perfect dose. I stopped at 21mg because I'm not sure when to stop? How did you know when to stop? Which symptoms are helped the most in your mind?
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02-16-2014, 11:13 PM | #59 | ||
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I get that there could be many causes of PD, but don't get why research keeps hammering away on the alpha-synuclein when from everything I have read over the past many years, it is NOT the hallmark it is portrayed to be. I don't have links, sorry, this is my take from cumulative reading over many years. If someone is dx'd with PD and takes PD drugs for years, but on autopsy, if one is even done, there are no synuclein clumps found----they proclaim no PD. Yet, that person took drugs for that illness for years, suffered, insurance paid for scripts, doc visits, etc.... Maybe by scrutinizing synuclein they will discover what its function(s) is/are, as they don't even know that. Hopefully. |
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02-17-2014, 02:39 PM | #60 | ||
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