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08-19-2010, 09:22 AM | #1 | |||
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In Remembrance
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Come with me on a flight of fantasy for a minute and entertain a radical idea. Suppose that there is, for lack of a better term, a "metabolic pattern" built into our DNA that produces both PD and diabetes (and perhaps other conditions as well) when certain conditions exist.
I ran across an article in Science Daily. I am going to take some major liberties and completely recycle the article by substituting PD for diabetes: "<PD> is caused by an inability of the <neurons> in the <substantia nigra> to produce enough of the <neurotransmitter dopamine> to meet the body's needs. Central to this is a loss of <neuronal> function and mass as a result of <dopamine> resistance (the inability of cells in the body to respond appropriately to <dopamine>). New insight into how <dopamine> resistance leads to loss of <neuronal> mass has now been provided by studies ..... In the study, in the absence of the protein <"X">, the symptoms of <PD> improved in two mouse models of the disease.... <"X"> is a protein that is involved in promoting the death of a cell that is under stress because it is producing more <dopamine> than it is able to handle. The authors therefore propose that <dopamine> resistance causes <neurons> to make more <dopamine> than they can handle, such that the stress signaling pathways that activate <"X"> are initiated and the <neurons> die.... Mere musings, but does dopamine resistance exist?
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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