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-   -   So which "existing" diabetes drug turns the PGC-1 Alpha "Master Switch" back on? (https://www.neurotalk.org/parkinson-s-disease/134572-existing-diabetes-drug-pgc-1-alpha-master-switch.html)

reverett123 10-09-2010 08:58 AM

My money is betting that they are talking about Exendine-4 that Tom Isaacs is flogging gila monsters to produce. I found a corporate presentation for investors from early this year at pharmain.com/pdfs/Non-ConfidentialTechnologyPresentation.pdf

Download and look at the last three or four pages. Among other interesting tid bits are "PGC protects GLP-1 from DPP-IV degradation". That is exactly what Tom and crew are into. GLP-1 is the peptide that rebuilds the brain and DPP-IV is the enzyme that prevents it from working.

lurkingforacure 10-09-2010 09:23 AM

I read this also
 
Quote:

Originally Posted by villiers (Post 702909)
it seems cinnamon & extra virgin coconut oil supplementation might do the job as good as a diabete drug concerning the PGC-1 Alpha
Alzeihmer is considered more&more as a diabete type 3 (cognitive diabete)
i invite you to read this !!!!!!!!!!!!

coconut oil
http://alzheimers.infopop.cc/eve/for...261/m/63910335

cinnamon
http://alzheimers.infopop.cc/eve/for...1/m/6051008062

Yep, I read about the connection between Alz. and diabetes some time ago, glad to see others are looking into this as well. And I have also read that the coconut oil helps with other dementias, not just Alz. Rick posted a thread about a gentleman taking coconut oil who was improving cognitively, so there is definitely something to that oil. I've also read it helps with constipation, FYI.

paula_w 10-09-2010 09:42 AM

received a reply
 
From Katie Hood in part: "I know we've led a lot of work on pioglitazone in PD. what's exciting is that we just launched/are launching a new "repurposing" RFA - meant to specifically fund work to show that drugs developed for other diseases might help PD. $3M i believe. so work like this has a way to get funded!"

From Todd Sherer: "Just for more information, based on work supported
by the MJFF, the NIH has awarded funding for a clinical trial on
pioglitazone that is scheduled to start early next year."

Thanks to you both for responding!

caldeerster 10-09-2010 01:35 PM

That's good news
 
Thanks for that, Paula.

The ongoing exendin trial in the UK may provide some answers as well. Is anyone here participating in that trial or knows someone who is?



Quote:

Originally Posted by paula_w (Post 702955)
From Katie Hood in part: "I know we've led a lot of work on pioglitazone in PD. what's exciting is that we just launched/are launching a new "repurposing" RFA - meant to specifically fund work to show that drugs developed for other diseases might help PD. $3M i believe. so work like this has a way to get funded!"

From Todd Sherer: "Just for more information, based on work supported
by the MJFF, the NIH has awarded funding for a clinical trial on
pioglitazone that is scheduled to start early next year."

Thanks to you both for responding!


Conductor71 10-09-2010 08:57 PM

This sounds even better
 
Quote:

Originally Posted by reverett123 (Post 702946)
My money is betting that they are talking about Exendine-4 that Tom Isaacs is flogging gila monsters to produce. I found a corporate presentation for investors from early this year at pharmain.com/pdfs/Non-ConfidentialTechnologyPresentation.pdf

Download and look at the last three or four pages. Among other interesting tid bits are "PGC protects GLP-1 from DPP-IV degradation". That is exactly what Tom and crew are into. GLP-1 is the peptide that rebuilds the brain and DPP-IV is the enzyme that prevents it from working.

Wow. Hadn't heard of this potential treatment. Tom must be doing something right; it looks like clinical trials (pilot study) on Exendin-4 for PD is now recruiting participants in the UK. This would move through FDA hoops so much the sooner.

Exendin-4 as a Treatment for Parkinson's

lurkingforacure 10-10-2010 01:07 PM

what about cogane?
 
Quote:

Originally Posted by reverett123 (Post 702946)
My money is betting that they are talking about Exendine-4 that Tom Isaacs is flogging gila monsters to produce. I found a corporate presentation for investors from early this year at pharmain.com/pdfs/Non-ConfidentialTechnologyPresentation.pdf

Download and look at the last three or four pages. Among other interesting tid bits are "PGC protects GLP-1 from DPP-IV degradation". That is exactly what Tom and crew are into. GLP-1 is the peptide that rebuilds the brain and DPP-IV is the enzyme that prevents it from working.

I thought Isaacs headed up the Cure PD Trust over there which was claiming Cogane was the "cure" for PD we have al been waiting for?....but not really, if he is really working on this? What does this say about Cogane, which is to start trials here in the US early next year?

reverett123 10-10-2010 04:57 PM

Tom and the Trust are miniature versions of MJFF and raise funds for multiple studies.


Quote:

Originally Posted by lurkingforacure (Post 703215)
I thought Isaacs headed up the Cure PD Trust over there which was claiming Cogane was the "cure" for PD we have al been waiting for?....but not really, if he is really working on this? What does this say about Cogane, which is to start trials here in the US early next year?


paula_w 10-10-2010 10:23 PM

Again
 
Quote:

Originally Posted by reverett123 (Post 703252)
Tom and the Trust are miniature versions of MJFF and raise funds for multiple studies.

let's keep it going i need more information - is that ok? i have a good feeling about this.


paula

TommyI 10-11-2010 04:00 PM

Sorry all. Been ill since wpc and trying to catch up.

For the record neither I nor anyone else at CPT has ever said Cogane will be the "cure" for Parkinson's. We continue to be excited about the product and our support of it assisted the pharma company which owns it in securing funding to the tune of £25million. Without our support the product might never have made it to clinical trial - so feel rather disgruntled about negative comments, but perhaps I misread them and no matter anyway. Just wanted to get that straight. No need for further comment.

Exendin - yes - it's looking more and more exciting particularly in view of articles which I am forwarding to Rick as I don't know how to attach them here. PIlot study has started a Queen Square in LOndon. Will keep you posted.

Tom

paula_w 10-12-2010 07:15 AM

hope you're feeling better
 
It's no wonder you came down with something. What a job it must have been to pull that off! We enjoyed it and see you have a very nice group working with you. It was a wonderful place to hang out but i thihk each wii machine has their own 'slant' as my bowling was terrible and i'm pretty decent at home.

:winky:


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