Parkinson's Disease Tulip


advertisement
Reply
 
Thread Tools Display Modes
Old 10-06-2010, 09:03 PM #1
caldeerster caldeerster is offline
Junior Member
 
Join Date: Aug 2007
Posts: 81
15 yr Member
caldeerster caldeerster is offline
Junior Member
 
Join Date: Aug 2007
Posts: 81
15 yr Member
Default So which "existing" diabetes drug turns the PGC-1 Alpha "Master Switch" back on?

Possibly this one?

http://jap.physiology.org/cgi/content/full/101/6/1685

Metformin increases the PGC-1 protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo

http://en.wikipedia.org/wiki/Metformin
caldeerster is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
imark3000 (10-07-2010)

advertisement
Old 10-06-2010, 09:24 PM #2
Conductor71's Avatar
Conductor71 Conductor71 is offline
Senior Member
 
Join Date: Jul 2009
Location: Michigan
Posts: 1,474
10 yr Member
Conductor71 Conductor71 is offline
Senior Member
Conductor71's Avatar
 
Join Date: Jul 2009
Location: Michigan
Posts: 1,474
10 yr Member
Default Good question

Quote:
Originally Posted by caldeerster View Post
Possibly this one?

http://jap.physiology.org/cgi/content/full/101/6/1685

Metformin increases the PGC-1 protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo

http://en.wikipedia.org/wiki/Metformin
I am thinking this class of drugs:

Thiazolidinediones one of which is Pioglitazone which I remembered seeing that it was a diabetic drug that held promise for treating Parkinson's

Here is an article on it from 2006


I find it interesting that we have an endocrine link...who is it here that strongly feels PD is linked to insulin metabolism...is it Bluedhalia?

Laura
Conductor71 is offline   Reply With QuoteReply With Quote
Old 10-06-2010, 09:51 PM #3
caldeerster caldeerster is offline
Junior Member
 
Join Date: Aug 2007
Posts: 81
15 yr Member
caldeerster caldeerster is offline
Junior Member
 
Join Date: Aug 2007
Posts: 81
15 yr Member
Default Thanks for the link

That was four years ago. Have they started a trial yet?


Quote:
Originally Posted by Conductor71 View Post
I am thinking this class of drugs:

Thiazolidinediones one of which is Pioglitazone which I remembered seeing that it was a diabetic drug that held promise for treating Parkinson's

Here is an article on it from 2006


I find it interesting that we have an endocrine link...who is it here that strongly feels PD is linked to insulin metabolism...is it Bluedhalia?

Laura
caldeerster is offline   Reply With QuoteReply With Quote
Old 10-06-2010, 10:13 PM #4
Conductor71's Avatar
Conductor71 Conductor71 is offline
Senior Member
 
Join Date: Jul 2009
Location: Michigan
Posts: 1,474
10 yr Member
Conductor71 Conductor71 is offline
Senior Member
Conductor71's Avatar
 
Join Date: Jul 2009
Location: Michigan
Posts: 1,474
10 yr Member
Default We're talking the world of research alternate universe

Quote:
Originally Posted by caldeerster View Post
That was four years ago. Have they started a trial yet?
Yep, that's why I wondered whether this was just old but updated news which essentially it is. Researchers were onto this four years go, but I guess the genetic link and the master switch thing are the key new developments.

The brand name is Actos. I guess this is one of the few that doesn't have nasty cardiac side effects. There is a really great article in Nature on all of this. You'll love this quote:

... a clinical trial to test Actos in patients with Parkinson's disease has already been approved by regulators.

Nature article

No trial to date that I can find at clinicaltrials.gov

Laura
Conductor71 is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
imark3000 (10-07-2010)
Old 10-06-2010, 10:20 PM #5
caldeerster caldeerster is offline
Junior Member
 
Join Date: Aug 2007
Posts: 81
15 yr Member
caldeerster caldeerster is offline
Junior Member
 
Join Date: Aug 2007
Posts: 81
15 yr Member
Default I looked there too

Couldn't find anything.

There is a new trial of Byetta (another Diabetes drug) that is taking place in England. But I don't know if it stimulates this particular protein.

The link you provided says that MJFF provided some funding for the study. I don't get why four years have gone by without a trial.

Cal


Quote:
Originally Posted by Conductor71 View Post
Yep, that's why I wondered whether this was just old but updated news which essentially it is. Researchers were onto this four years go, but I guess the genetic link and the master switch thing are the key new developments.

The brand name is Actos. I guess this is one of the few that doesn't have nasty cardiac side effects. There is a really great article in Nature on all of this. You'll love this quote:

... a clinical trial to test Actos in patients with Parkinson's disease has already been approved by regulators.

Nature article

No trial to date that I can find at clinicaltrials.gov

Laura
caldeerster is offline   Reply With QuoteReply With Quote
Old 10-08-2010, 09:25 AM #6
paula_w paula_w is offline
In Remembrance
 
Join Date: Aug 2006
Location: Florida
Posts: 3,904
15 yr Member
paula_w paula_w is offline
In Remembrance
 
Join Date: Aug 2006
Location: Florida
Posts: 3,904
15 yr Member
Default

Published online 6 October 2010 | Nature | doi:10.1038/news.2010.518

News
Damaged cell powerhouses linked to Parkinson's
New uses for old drugs

Such drugs have already been widely pursued as potential therapies for type 2 diabetes, and some have already been approved for that use. Avandia (rosiglitazone), a diabetes drug recently pulled from the European market because it raises the risk of heart attack, activates a key protein in the PGC-1α pathway.

But a related drug called Actos (pioglitazone) has not been firmly linked to heart attack and remains in use. Beal says that a clinical trial to test Actos in patients with Parkinson's disease has already been approved by regulators.

http://www.nature.com/news/2010/1010....2010.518.html

no mention of metformin altho it sounds safe for diabetes.
__________________
paula

"Time is not neutral for those who have pd or for those who will get it."

Last edited by paula_w; 10-08-2010 at 09:29 AM. Reason: duh just read laura's again...same study
paula_w is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
caldeerster (10-08-2010)
Old 10-08-2010, 11:21 AM #7
Conductor71's Avatar
Conductor71 Conductor71 is offline
Senior Member
 
Join Date: Jul 2009
Location: Michigan
Posts: 1,474
10 yr Member
Conductor71 Conductor71 is offline
Senior Member
Conductor71's Avatar
 
Join Date: Jul 2009
Location: Michigan
Posts: 1,474
10 yr Member
Default What happened to it?

Quote:
Originally Posted by paula_w View Post

But a related drug called Actos (pioglitazone) has not been firmly linked to heart attack and remains in use. Beal says that a clinical trial to test Actos in patients with Parkinson's disease has already been approved by regulators.

http://www.nature.com/news/2010/1010....2010.518.html

no mention of metformin altho it sounds safe for diabetes.
Paula,

We're onto that, but Actos was first brought up in the news four years ago! MFJJ funded the initial study and there has been no movement on it. I searched for the lead researchers name "Marina Emborg" and it doesn't even look like it is on her radar...another possible major treatment sucked into the black hole.

If Debi Brooks is reading...help!

Laura
Conductor71 is offline   Reply With QuoteReply With Quote
Old 10-08-2010, 04:21 PM #8
caldeerster caldeerster is offline
Junior Member
 
Join Date: Aug 2007
Posts: 81
15 yr Member
caldeerster caldeerster is offline
Junior Member
 
Join Date: Aug 2007
Posts: 81
15 yr Member
Default I second that - Debi Brooks can you give us an update? TIA!

Thanks Laura

Cal

Quote:
Originally Posted by Conductor71 View Post
Paula,

We're onto that, but Actos was first brought up in the news four years ago! MFJJ funded the initial study and there has been no movement on it. I searched for the lead researchers name "Marina Emborg" and it doesn't even look like it is on her radar...another possible major treatment sucked into the black hole.

If Debi Brooks is reading...help!

Laura
caldeerster is offline   Reply With QuoteReply With Quote
Old 10-08-2010, 08:18 PM #9
paula_w paula_w is offline
In Remembrance
 
Join Date: Aug 2006
Location: Florida
Posts: 3,904
15 yr Member
paula_w paula_w is offline
In Remembrance
 
Join Date: Aug 2006
Location: Florida
Posts: 3,904
15 yr Member
Default emailed

...debi brooks and katie hood; hope they know, could it possibly be under wraps? Does it involve a separate patent?
__________________
paula

"Time is not neutral for those who have pd or for those who will get it."
paula_w is offline   Reply With QuoteReply With Quote
Old 10-09-2010, 06:06 AM #10
villiers villiers is offline
Junior Member
 
Join Date: Feb 2010
Location: Paris,France
Posts: 96
10 yr Member
villiers villiers is offline
Junior Member
 
Join Date: Feb 2010
Location: Paris,France
Posts: 96
10 yr Member
Default

it seems cinnamon & extra virgin coconut oil supplementation might do the job as good as a diabete drug concerning the PGC-1 Alpha
Alzeihmer is considered more&more as a diabete type 3 (cognitive diabete)
i invite you to read this !!!!!!!!!!!!

coconut oil
http://alzheimers.infopop.cc/eve/for...261/m/63910335

cinnamon
http://alzheimers.infopop.cc/eve/for...1/m/6051008062
villiers is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
Conductor71 (10-09-2010), imark3000 (10-10-2010), moondaughter (10-09-2010)
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
A Definition Question- re meaning of "Full Body RSD" and "Internal RSD" ?? Cake Reflex Sympathetic Dystrophy (RSD and CRPS) 12 04-28-2013 10:47 AM
Statins & Niacin - (and regarding "No-Flush" vs "Sustained Release" OneMoreTime Vitamins, Nutrients, Herbs and Supplements 5 01-12-2010 04:41 AM
Actor Patrick Swayze, star of "Dirty Dancing" and "Ghost," FaithS The Stumble Inn 12 09-16-2009 04:42 PM
"Hundreds Dead" in Failed Diabetes Drug Trial lou_lou Diabetes / Insulin Resistance / Metabolic Syndrome 3 12-19-2008 12:18 PM
"Instant Karma" - the Voices of Apathy -"Coulter and Limbaugh" lou_lou Parkinson's Disease 0 11-02-2006 05:20 PM


All times are GMT -5. The time now is 05:37 PM.

Powered by vBulletin • Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.