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10-06-2010, 09:03 PM | #1 | ||
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Junior Member
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Possibly this one?
http://jap.physiology.org/cgi/content/full/101/6/1685 Metformin increases the PGC-1 protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo http://en.wikipedia.org/wiki/Metformin |
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"Thanks for this!" says: | imark3000 (10-07-2010) |
10-06-2010, 09:24 PM | #2 | |||
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Senior Member
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Quote:
Thiazolidinediones one of which is Pioglitazone which I remembered seeing that it was a diabetic drug that held promise for treating Parkinson's Here is an article on it from 2006 I find it interesting that we have an endocrine link...who is it here that strongly feels PD is linked to insulin metabolism...is it Bluedhalia? Laura |
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10-06-2010, 09:51 PM | #3 | ||
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Junior Member
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That was four years ago. Have they started a trial yet?
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10-06-2010, 10:13 PM | #4 | |||
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Senior Member
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Yep, that's why I wondered whether this was just old but updated news which essentially it is. Researchers were onto this four years go, but I guess the genetic link and the master switch thing are the key new developments.
The brand name is Actos. I guess this is one of the few that doesn't have nasty cardiac side effects. There is a really great article in Nature on all of this. You'll love this quote: ... a clinical trial to test Actos in patients with Parkinson's disease has already been approved by regulators. Nature article No trial to date that I can find at clinicaltrials.gov Laura |
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"Thanks for this!" says: | imark3000 (10-07-2010) |
10-06-2010, 10:20 PM | #5 | ||
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Junior Member
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Couldn't find anything.
There is a new trial of Byetta (another Diabetes drug) that is taking place in England. But I don't know if it stimulates this particular protein. The link you provided says that MJFF provided some funding for the study. I don't get why four years have gone by without a trial. Cal Quote:
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10-08-2010, 09:25 AM | #6 | ||
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In Remembrance
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Published online 6 October 2010 | Nature | doi:10.1038/news.2010.518
News Damaged cell powerhouses linked to Parkinson's New uses for old drugs Such drugs have already been widely pursued as potential therapies for type 2 diabetes, and some have already been approved for that use. Avandia (rosiglitazone), a diabetes drug recently pulled from the European market because it raises the risk of heart attack, activates a key protein in the PGC-1α pathway. But a related drug called Actos (pioglitazone) has not been firmly linked to heart attack and remains in use. Beal says that a clinical trial to test Actos in patients with Parkinson's disease has already been approved by regulators. http://www.nature.com/news/2010/1010....2010.518.html no mention of metformin altho it sounds safe for diabetes.
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paula "Time is not neutral for those who have pd or for those who will get it." Last edited by paula_w; 10-08-2010 at 09:29 AM. Reason: duh just read laura's again...same study |
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"Thanks for this!" says: | caldeerster (10-08-2010) |
10-16-2010, 06:58 PM | #7 | |||
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Member
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Thanks for including the "Nature" article. If I was reading it correctly, the regulators, referred to in the article, are in Europe. So perhaps there is a trial going on there. I am definitely going to look into Actos after seeing the Science Daily article today on research from Harvard. |
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07-13-2011, 11:23 AM | #8 | ||
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Banned User
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It would be important to realize that activation of PGC-1 {alpha} and {beta} has severe side effects that can occur during a treatment:
Below a summary about the possible problems: - When PGC-1 {alpha} or {beta} are higher in the muscle, tumor necrosis factor {alpha} (TNF {alpha}) is elevated. More TNF {alpha}, a mediator of inflammation, is secreted into the blood (cf. Olesen J et al; Medicine & Science in Sports & Exercise: October 2010 - Volume 42 - Issue 10 - p 58. - The same article shows this at basal levels and that it worsens following injection of TNF into muscle. - When PGC-1 is elevated more lipids are accumulating in muscle. People can become obese. Lipids often induce inflammation (cf. Summermatter S et al; Journal of biological chemistry: October 2010 22;285(43):32793-800) - Then PGC-1 can even induce diabetes when too high (cf. Miura S, Journal of biological chemistry: August 2003 15;278(33):31385-90.) - High PGC-1 {alpha} and {beta} levels, basal and after stimulation by TNF or Lipopolysaccharide (LPS) lead to high expression and release of inflammatory IL (interleukin) and of macrophage infiltration as indicated by CD (cluster of differentiation) All this should be kept in mind. Maybe it's still ok to develop drugs that promote PGC-1, but it should be considered that this can have these side effects. |
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"Thanks for this!" says: | paula_w (07-13-2011) |
10-13-2010, 09:09 PM | #9 | |||
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In Remembrance
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Those following this subject might find this of interest.
http://onlinelibrary.wiley.com/doi/1...10.00090.x/pdf
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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"Thanks for this!" says: | RLSmi (10-14-2010) |
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