FAQ/Help |
Calendar |
Search |
Today's Posts |
10-16-2010, 10:18 AM | #1 | |||
|
||||
Senior Member
|
Key to Blood-Brain Barrier Opens Way for Treating Alzheimer’s and Stroke
ScienceDaily (Oct. 15, 2010) — While the blood-brain barrier (BBB) protects the brain from harmful chemicals occurring naturally in the blood, it also obstructs the transport of drugs to the brain. In an article in Nature scientists at the Swedish medical university Karolinska Institutet now present a potential solution to the problem. The key to the BBB is a cell-type in the blood vessel walls called pericytes, and the researchers hope that their findings will one day contribute to new therapies for diseases like Alzheimer's and stroke. "Our new results show that the blood-brain barrier is regulated by pericytes, and can be opened in a way that allows the passage of molecules of different sizes while keeping the brain's basic functions operating properly," says Christer Betsholtz... "Another interesting find is that the cancer drug Imatinib, which inhibits certain signal proteins for cell growth, has a similar effect in the presence of pericytes in that they also close the capillary wall transport paths," says Professor Christer Betsholtz. http://www.sciencedaily.com/releases...1014083341.htm
__________________
In the last analysis, we see only what we are ready to see, what we have been taught to see. We eliminate and ignore everything that is not a part of our prejudices. ~ Jean-Martin Charcot The future is already here — it's just not very evenly distributed. William Gibson |
|||
Reply With Quote |
10-16-2010, 10:44 AM | #2 | |||
|
||||
Senior Member
|
(all this seems interesting though not applicable at present to me. Have noticed the term "NGF dysfunction ": seems nerve growth dysfunction is the newest "dysfunction theory" in PD. recent reports on DJ1[PARk7] and PD)
http://www.sciencedaily.com/releases...1001163342.htm Parkinson's: Excess of Protein Suggests New Target for Treatment With Widely Used Anti-Cancer Drug Imatinib ScienceDaily (Oct. 4, 2010) ‹ Johns Hopkins scientists have discovered that the over-activation of a single protein may shut down the brain-protecting effects of a molecule and facilitate the most common form of Parkinson's disease... Previous research demonstrated that a protein called parkin protects brain cells by "tagging" certain toxic elements that are then destroyed naturally. It was also known that mutations in the gene that holds the code for parkin cause rare, familial forms of PD. However, parkin's role remained unclear in sporadic late-onset PD, the prevalence of which is increasing as the population ages... ...Results of the new study, published Sept. 7 in the Proceedings of the National Academy of Sciences (PNAS) Online Early Edition, indicate that an over-activation of a protein called c-Abl- can shut down the activity of parkin and contribute to a build-up of toxic proteins that kill brain cells and enables the progression of PD. C-Abl contributes to the regulation of cell death and is implicated in a host of diseases. It has already has proven to be a target for certain types of cancer-killing drugs, such as imatinib (Gleevec), the first drug designed to directly switch off a biochemical signal that directly targets a protein vital to cancer growth, says Ted Dawson, M.D., Ph.D...
__________________
In the last analysis, we see only what we are ready to see, what we have been taught to see. We eliminate and ignore everything that is not a part of our prejudices. ~ Jean-Martin Charcot The future is already here — it's just not very evenly distributed. William Gibson |
|||
Reply With Quote |
Reply |
|
|
Similar Threads | ||||
Thread | Forum | |||
Blood-Brain Barrier | Parkinson's Disease | |||
Blood Brain Barrier in ALS | ALS | |||
Blood Brain Barrier | Parkinson's Disease | |||
Blood Brain Barrier | Multiple Sclerosis | |||
The Blood Brain Barrier | Parkinson's Disease |