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10-19-2010, 11:29 AM
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MJFF Announces New Funding Opportunity: Repositioning Drugs for PD 2011 News Categories: Funding News, MJFF-Funded Projects Today, MJFF announces a new funding opportunity, called “Repositioning Drugs for PD 2011”. The $3 million program will provide funding for up to three years for preclinical or clinical projects proposing to study clinically safe compounds (originally developed for other conditions) as treatments for PD. HTML Code:
Two types of drugs are relevant for this request for applications (RFA): compounds that have passed clinical safety tests, but have failed efficacy trials for nonPD conditions, and compounds that have already been approved and are on the market for nonPD conditions. I have a request for this forum. I have seen several posts from forum members in the past about FDA approved drugs for non-PD disorders working reasonably well for PD, for example Calcium channel blockers. If you have such information (personal experiences or web-based info), could you please post it again? We may already have a "non-scientific" validation of some of these drugs. Thanks Girija |
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10-19-2010, 02:50 PM
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In Remembrance
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http://parkinsonsonline.org/blog2/?p=140
Girija- This is from my blog "Brainstorm" and is a listing of about 100 promising therapeutics. While the majority will not be appropriate it may give you ideas. -Rick
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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10-20-2010, 10:02 PM
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I've been taking amlodipine because it was the best cc blocker I could obtain from Kaiser, thinking (hoping) it was similar enough to isradipine. Turns out apparently not. The other thing I did soon after diagnosis was to slap on a low-dose bio-identical estrogen patch, since I've read several times about an estrogen-PD connection. Just one example: women who get full hysterectomies (including ovaries) before age 50 have a higher risk of PD, and risk increases the younger the age at removal.
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| "Thanks for this!" says: | girija (10-21-2010) |
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10-20-2010, 11:07 PM
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Senior Member
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Researchers are just now starting to explore how PD is different for women, and we just posted an article abstract in another thread that suggests sex hormones may be treatment approaches down the road. Progesterone is thought to play a key role as well in neurodegenerative disease as well. Laura |
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"Repositioning drugs for PD" from MJFF
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