FAQ/Help |
Calendar |
Search |
Today's Posts |
10-22-2010, 10:39 AM | #1 | ||
|
|||
Magnate
|
|
||
Reply With Quote |
10-22-2010, 01:23 PM | #2 | |||
|
||||
Senior Member
|
Quote:
This is one to watch. Laura |
|||
Reply With Quote |
10-25-2010, 01:17 PM | #3 | |||
|
||||
Senior Member
|
Bump.
If you wonder where freezing and slow movement come from and why it is only our habitual, automatic movements that are impacted, read the article Soccertese posted. It seems to make a lot of sense to me and hopefully this will lead to improved treatments in the future or targeted neuroprotection. |
|||
Reply With Quote |
10-25-2010, 03:56 PM | #4 | ||
|
|||
Member
|
Laura,
“Numerous experiments show that the loss of dopamine from the basal ganglia increases inhibitory output from the habitual control circuits” I happen to be a control engineer and the article sighted makes some sense to me. Any man made dynamic system (for example the control system driving a rocket) must include a feed forward signal defining the immediate goal for movement (intention) AND a feed back signal quantifying the actual movement achieved. In engineering terms the feed back signal is used to attenuate and correct the feed forward signal (i.e. inhibitory and it is typically called a negative feed back signal). Of course this happens in a continuous manner in infinitesimal small steps. The science of man made control systems essentially aims at smooth movement by manipulating the feed back signal. For example, too much negative feed back signal will make movement sluggish. Too little (negative feedback) may result in uncontrolled or oscillatory movement. This is a simplified picture and hope it helps. Imad Last edited by imark3000; 10-25-2010 at 06:29 PM. |
||
Reply With Quote |
"Thanks for this!" says: | Conductor71 (10-25-2010), violet green (10-28-2010) |
10-25-2010, 07:51 PM | #5 | ||
|
|||
Senior Member
|
Imad, I remember reading an article in which the cause of tremor was described exactly in the same terms as as your engineering model, interestingly rigidity was also postulated in the same way - as a fine extreme of oscillation, and linked to the sensation of 'internal tremor' that many pwp with no apparent tremor feel...... for those of us who had no way to describe this prior to dx it was often put down to panic attacks, which I KNEW was not the case! It is fascinating that there is a mechanical/physical model there.....
neurotransmitters again, I think..... |
||
Reply With Quote |
"Thanks for this!" says: | imark3000 (10-25-2010) |
Reply |
|
|
Similar Threads | ||||
Thread | Forum | |||
Another study that gets us one step closer to a cure | Traumatic Brain Injury and Post Concussion Syndrome | |||
Lessons from yeast: A possible cure for Parkinson's disease? | Parkinson's Disease | |||
Scientists Say Cure for Parkinson's Disease Right under Their Noses | Parkinson's Disease | |||
Research Gets Closer to Origin of Parkinson's Disease | Parkinson's Disease | |||
Highly Promising Dutch Research Into Alzheimer's Disease and Parkinson's Disease | Parkinson's Disease |