Now this makes me wonder, I lived in Hawaii for 12 years. For some insane reason that only psych ward doctors would understand, I returned to Ohio. 14 years later was dx'ed with PD.

A now dated article detailing mitochondrial cytopathies and its treatment, written by 2 specialists in mitochondrial diseases. http://www.ccjm.org/content/68/7/625.full.pdf+html

Vitamins, supplements, and medications
used in mitochondrial diseases
SUPPLEMENT DAILY DOSE COMMENTS
Coenzyme Q10 5–15 mg/kg in divided doses Variable gastrointestinal absorption dependent
on formulation
Maximal benefit may take months
L-carnitine 30–100 mg/kg in divided doses Prescription brand Carnitor
IV and oral preparations available
Thiamine (vitamin B1) 100–800 mg
Riboflavin (vitamin B2) 400 mg
Niacinamide (vitamin B3) 100–500 mg Avoid niacin form, as it can cause uncomfortable flushing
Folate 1–10 mg
Vitamin E 400–1200 IU in divided doses May interfere with CoQ10 absorption
Selenium 25–50 mg
Lipoic acid 200–600 mg in divided doses
Prednisone 5–60 mg Symptomatic improvement noted on patients,
but should be used sparingly as withdrawal of treatment
may lead to recurrence of symptoms

In addition, the UMDF site has recommended therapies for mt dysfunction:
http://www.umdf.org/site/c.otJVJ7MMI..._Therapies.htm

Ribose is part of the molecule adenosine.

It exists in the mitochondria as AMP,ADP and ATP.

It also exists outside the cell as a modulator of neurotransmitter receptors, and is the first step in initiating sleep.

It is also used medically. I have that link on that thread I posted.

Since ribose is not found in appreciable amounts in food, we don't consume it very much. It is part of riboflavin Vit B2.

OK - I'd been taking 5,000 IU in the AM and 5,000 more in the PM. Ran low and reordered but holiday shipping forced me to cut back to 4,000 IU yesterday and 800 IU this morning. By 3:00 this afternoon I was lying in the floor feeling the familiar crappy way of "waiting for a pill" that I hadn't felt since I began two weeks ago. My wife came in with the mail and the awaited shipment. I took 5,000 IU at 3:15 and by 3:30 was fully operational.

Assuming that this wasn't coincidence, this suggests that in addition to any long term healing there is also an element of symptom relief here. All I know is that I feel good.

Tomorrow I will start the day with the full 10,000 and see if the morning goes differently.

Just curious if you have noticed any ill effects from the doseage you have been taking daily? I want to test myself. Would be happy with anything close to the improvements you are getting. Thanks for sharing.

As you raise the D3 ( to really high levels), I think it is prudent to not take calcium supplements. D3 improves absorption of calcium from food and dairy, and may lead to hypercalcemia, if you are not careful.

Keep that in mind. 10,000 IU is the upper limit found to be safe,
in recent studies. But those studies did not go for long periods of time.

No, thus far I have noted none. Some of the studies (noted by PubMed ID #) and dosages used as well as outcome:

20565345 - 50,000 IU per day for ten days was compared to a 3,000 IU per day for 30 days followed by 1,000 IU per day for 60 more - Neither caused any problems.

17874029 - 300,000 IU one-time oral dose - No problems.

19244376 - 5,000 IU daily for 12 months - No poblems.

20130093 - 8400 IU weekly for unspecified time - No problems.

17823429 - Over a 28-week period with MS patients, increased from 28,000 IU weekly to 280,000 weekly - No problems.

18275686 - 4000 IU to 8000 IU daily over a six-year period - No problems.

18991184 - 300,000 IU single dose - No problems.

Good luck.

What those studies looked for were kidney stones and blood levels.

But there is a cardiologist with a blog who suggests slow increases in calcium in the serum may contribute to atherosclerosis.

http://heartscanblog.blogspot.com/20...vitamin-d.html

There is also another factor to consider with high D3 use.

If one is low in magnesium, it will affect the D3 activity.
This link is at the Vitamin D council website.

from http://www.vitamindcouncil.org/

Unfortunately the way that website is organized, links to specific articles all share the same address.

I've read many places that most americans are deficient in magnesium..modern diet simply does not contain the foods which give us this.

Just wanted to share that a very easy way to get magnesium is to take epsom salt baths. No fear of getting diarrhea this way, either. You can buy something like ten pounds of epsom salts at Costco for a few bucks, it's almost funny how cheap it is.