Teresa, what a treat to hear from you! I think we all understand your absence from our little group, but would love to hear from you occasionally.

You mentioned in the other thread that you are more pessimistic. That is, of course, something that all of us fight from time to time. If it helps, know that we think of you often and will be glad to hear from you regardless of how you feel.

OLE CS gotta love that, and Steff I almost peeded my pants we forget the british dont always get our weird sayings (the U.s of course not canada ) my daughters other half is from blackpool and thinks we're all nuts lol but really cs good to see you feeling better I'm on morphine for my back but makes me sick, doesnt sound like you get that, do you ?would it be more of a booster for the ms contin I'm going on somthing soon don't know what yet I've been dx with clinical depression (LIKE HELL I said ) they got kind of funny when I said no suiciadal thoughts murder maybe dam tipped them off , oh just to make sure nobody misunderstands I work with the public has nothing to do with hubby (well a wee bit of hurting might be okay lol anywaY hon talk soon and just really glad your feeling better every bit helps hope yoy got the basement nice and dry. where is the dam spell check on this thing aggggggggggggg

I only cuss out those who deserve it (imho), and if you've noticed, i've let a lot go by uncussed lately, cause it's not worth it. . Good to see you back.
Zuccini- You always give lots of good info, keep it up.
Robert- That was the best description of a "branded steer" i've ever heard
Gotta go, fingers spastic, can't type worth a damn. cs

dear cs,
I was given cymbalta by my Psychiatrist,today!
She believes it will be a good medication - she told me it could cause "Nausea"
how are you doing on the med, let me know?
It comes in a capsule! very unusual?
tell me your scientific cs - review so far - so good?
your sister,
me...

PS: it helps Fibromyalgia
http://www.medicinenet.com/script/ma...ticlekey=55350

cymbalta website:

http://www.cymbalta.com/index.jsp

tena's data:
I was frightened of the idea of change - but I took the capsule.
day 2, of taking cymbalta...

I did not realize how much pain I was having -
and now today
I have decided to reduce my MOTRIN use... teehee? that rhymes!

I can see straiight, or clearer - yes, dear cs, the fog has lifted.
so far -still palliative, but none the less -still thankful.

Combination pain management:


Eur J Pain. 2007 Feb;11(2):208-15. Epub 2006 Mar 20.
Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents.

* Jones CK,
* Peters SC,
* Shannon HE.

OBJECTIVES: The present study was undertaken to characterize whether the pharmacologic interaction between duloxetine, a balanced serotonergic and noradrenergic reuptake inhibitor, and the non-steroidal anti-inflammatory drug ibuprofen was simply additive, less than additive, or greater than additive (i.e., synergistic) in preclinical models of visceral and inflammatory pain, specifically acetic acid-induced writhing in mice and carrageenan-induced thermal hyperalgesia and mechanical allodynia in rats.

METHODS: In the writhing test, male CF-1 mice were injected intraperitoneally with 0.55% acetic acid and 5 min later the number of writhes was counted over a 5-min period. In the carrageenan models, male Sprague-Dawley rats were injected with a 1.5% carrageenan solution into the ventral surface of the hind paw; hypersensitivity to thermal and mechanical stimuli was subsequently evaluated 2h post-carrageenan.

RESULTS: Vehicle or a dose of duloxetine alone (1-100 mg/kg), ibuprofen alone (10-300 mg/kg), or duloxetine and ibuprofen in combination in a dose-ratio of 1:10 duloxetine:ibuprofen were orally administered 30 or 60 min before testing. Isobolographic analysis of the effects of duloxetine in combination with ibuprofen revealed a significant synergistic (greater than additive) interaction between duloxetine and ibuprofen both for reducing acetic acid-induced writhing and carrageenan-induced thermal hyperalgesia, but were additive for reversing mechanical allodynia.

CONCLUSIONS: Our data indicate that duloxetine and ibuprofen have synergistic efficacy in a visceral and an inflammatory pain model in rodents, and suggest that duloxetine and ibuprofen in combination may provide a useful approach to the clinical treatment of persistent pain, particularly inflammation-related pain.

PMID: 16542861 [PubMed - indexed for MEDLINE]

********************

Anesthesiology. 2002 Nov;97(5):1263-73.
Gabapentin and pregabalin can interact synergistically with naproxen to produce antihyperalgesia.

* Hurley RW,
* Chatterjea D,
* Rose Feng M,
* Taylor CP,
* Hammond DL.

Department of Anesthesia and Critical Care, and Committee on Neurobiology, University of Chicago, Illinois, USA.

BACKGROUND: Gabapentin and pregabalin are anticonvulsants with antihyperalgesic effects in animal models of neuropathic and inflammatory nociception. This study characterized the manner in which gabapentin or pregabalin interacts with naproxen to suppress thermal hyperalgesia and inflammation in the carrageenan model of peripheral inflammation. METHODS: Gabapentin, pregabalin, naproxen, or a fixed-dose ratio of gabapentin + naproxen or pregabalin + naproxen was administered orally to rats after the induction of inflammation by intraplantar injection of lambda-carrageenan in one hind paw. Nociceptive thresholds were determined by the radiant heat paw-withdrawal test. Paw edema was measured by plethysmometry. Drug plasma concentrations were determined by a liquid chromatography-mass spectroscopy-mass spectroscopy method.

RESULTS: Gabapentin, pregabalin, and naproxen alone reversed thermal hyperalgesia with ED50 values of 19.2, 6.0, and 0.5 mg/kg, respectively. Mixtures of gabapentin + naproxen in fixed-dose ratios of 50:1, 10:1, or 1:1 interacted synergistically to reverse carrageenan-induced thermal hyperalgesia. However, 1:50 gabapentin + naproxen produced only additive effects. No combination of gabapentin + naproxen decreased paw edema in a manner greater than additive. Plasma concentrations of gabapentin and naproxen were unaltered by the addition of the other drug. The mixture of 10:1 of pregabalin + naproxen interacted synergistically to reverse thermal hyperalgesia on the inflamed hind paw, whereas mixtures of 1:1 or 1:10 produced additive effects.

CONCLUSIONS: These data suggest that gabapentin + naproxen and pregabalin + naproxen can interact synergistically or additively to reverse thermal hyperalgesia associated with peripheral inflammation. Therefore, the use of gabapentin or pregabalin in low-dose combinations with naproxen may afford therapeutic advantages for clinical treatment of persistent inflammatory pain.

I was dxed about 1.5 yrs ago. I now take stalevo, mirapex and effexor. I have been noticing my pd is getting worse, walk is very stiff and clumsy, more pain, foggy headed, more jerking, tired all the time Anyway my depression is also getting worse, always seem to be in a funk. So went to my neurologist. He said, yep, your pd is progressing and added sinimet, 25 mg/ 3 times a day. I said, what about my depression. He said, let's wait and see if adding sinimet will relieve your depression, that can happen. It's been about 12 days now, and no let up on depression. If it doesn't seem to be working, I now am going to ask him about cymbalta, that is so good to know. And it helps with pain, that is a really good thing too. I take avinza and hydro for pain and would love to cut back on that.
Thank you for your help and thanks to God that I read it today. I hate miserably being depressed. I have suffered depression for a long time and it is a curse.

I have severe on off cycles and am always trying to cut back on sinemet to avoid dyskinesia. I hate the cramping and pain from my knees down when off. My feet ache and my toes curl and it hurts too much to stand up.

Four days on cymbalta and being off is a breeze. I can't walk, talk, or think that well but the pain is gone. I can handle half an hour or more of being frozen. The pain part of PD when off is hard to describe and underestimated. I didn't realize how nasty it was till it went away. I've been able to cut back on Sinemet and avoid being dyskinetic.

This forum is great. There are always a few people experiencing the same symptoms that a person can relate to. This is a tough battle we fight.

The best thing that I've found to fight PD with is the ability to learn how to live with it faster than it progresses. I am a much wiser and better person for having PD but at such a price. Cymbalta has really surprised me and made a big difference in just a few days. I really needed a good surprise right about now.

We are glad to help you -through our experiences...
WELCOME!

Coinciding with taking Cymbalta, I found it necessary to eliminate taking 25/100 Sinemet 8 times a day in order to avoid diskinesia! That's a HUGE reduction and after two weeks I'm doing and feeling better consistently! I've no explanation for this. I've needed those 800 mg of l-dopa for at least the past 3 years. Go figure. Does anyone have a guess as to what could possibly explain this? Doesn't make a lick of sense to me.