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01-07-2011, 08:48 AM
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[QUOTE=krugen68;732146]
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And of course a DAT or PET scan would see more dopamine in the brain after nicotine, because nicotine has that effect, making the neuron release more. But again, simply seeing more dopamine on the scan does not mean more neurons or receptors have been grown, just that there is more dopamine in the brain after a nicotine infusion. Forcing an already stressed neuron to produce or release more dopamine may not be a good thing. This is why we stopped the patch, plus, the therapuetic benefit began to really dissipate and not last as long...and of course when it wore off those offs became increasingly harder. |
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| "Thanks for this!" says: | krugen68 (01-07-2011) |
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01-07-2011, 09:29 AM
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[QUOTE=lurkingforacure;732442]
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In the clinical trial currently running in France they go to 90 mg, though some of his other trials went higher http://clinicaltrials.gov/ct2/show/NCT00873392 Apparently he took a patent out (with a n other ) for transdermal nicotine (patches) as opposed to the stop- smoking patches.
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Doctors are men who prescribe medicines of which they know little, to cure diseases of which they know less, in human beings of whom they know nothing” Voltaire |
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01-07-2011, 06:57 AM
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Doctors are men who prescribe medicines of which they know little, to cure diseases of which they know less, in human beings of whom they know nothing” Voltaire |
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01-07-2011, 07:11 AM
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Doctors are men who prescribe medicines of which they know little, to cure diseases of which they know less, in human beings of whom they know nothing” Voltaire |
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01-07-2011, 11:23 AM
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In a 2007 collaboration with researchers at the University of Pennsylvania and the University of Colorado at Boulder, Lester postdocs Raad Nashmi and Cheng Xiao and staff biologists Purnima Deshpande and Sheri McKinney created mice with fluorescent a4b2 receptors, and watched the results as the rodents received nicotine doses equivalent to a person smoking two to three packs per day. Over the course of a week or two, the mice sprouted significantly more a4b2 receptors in the midbrain, which processes rewards and is the seat of addiction. (Interestingly, Parkinson’s disease causes some dopamine-producing nerve cells within the midbrain to slowly die off.) When these cells were sprayed with nicotine, they fired about twice as often as cells from “nonsmoking” mice. “We’re essentially taking movies of events inside the neurons during the first minutes, hours, and days of nicotine addiction,” Lester says.
It appears that nicotine acts like a chaperone, a matchmaker, and a traffic cop inside the cell—a combination of roles that maximizes the odds that each nAChR the cell produces will actually reach the cell’s surface. As a chaperone, nicotine binds to nascent receptors’ subunits as they are being synthesized, preventing them from being chewed up by the cell. The details are still being worked out, but “the simple idea is that nicotine stabilizes the receptor in a conformation that does not appeal to the cell's mechanisms for eliminating poorly folded proteins,” says Lester. And, because the receptor’s binding box is made from amino acids on two of the five subunits, nicotine the matchmaker expedites their assembly by binding to the two free-floating halves of the box and holding them in the correct orientation. This gives the remaining three subunits something firm to latch onto, helping them fall into place. And finally, as the cell transports the newly assembled nAChRs to the neuron’s surface, the nicotine molecules bound to the receptors could act like a police escort, once again protecting them from the cell’s protein-digesting machinery. http://eands.caltech.edu/articles/LX...r_Nicotine.pdf
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Doctors are men who prescribe medicines of which they know little, to cure diseases of which they know less, in human beings of whom they know nothing” Voltaire |
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02-11-2012, 11:03 PM
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Junior Member
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Dear brothers and sisters in misery
I wanted to update you about my results with the Nicotine protocol ,that i am following since 14 months now. I am currently on 21 mg Nicotine patch + 1mg 1azilect per day +1 Sinemet LP 100/25 that i take 4 times per day My life has improved in a very consistent way,shaking has almost disappeared (i still shake sometimes but quite rarely),my fatigue has gone away,i used to sweat continuously,sweating has totally disappeared.foot dragging days are over . Stiffness is still present,but i would say i'm 50% less stiff . I started Sinemet 2 months before starting the Nicotine,and i don't think my wonderful improvements are only the results of levadopa...it seems the nicotine improved the "on time" in a spectacular way !! on off time,it depends...i would say better in general...sometimes excellent ,sometimes not good,very variable I still have bad days ,this is not a miracle unfortunately but i have a lot and a lot of good days . Very often,friends i had not seen for 1 year or many months, tell me that i seem to be way better than before . the bad side effects ? i would say that i sleep with more difficulties,sleep hours are shorter and that i am more paranoiac and susceptible . when i reached the 14 mg level,it took me 2 months to be able to get used to it,a lot of sleep problems,so i had to stay 6 months on the 14 mg level . But the overall quality of my life has so muuuch improved ,it's worth it for me . 2 months ago,i met up with my Neuro,who i had not visited since 9 months...it was a very good day (meaning that day,my on time was working very nicely ),it took him 10 mn to understand,to recognize who i was,he was a bit shocked and his words were "if this was the 1st time,i saw you in my office,i am not sure i could detect you as a PD person!!" this was wonderful to hear,but i am not gonna lie,there is days where my PD is quite flagrant still. this year,i have been able to go back to brazil(12 hours of flight ! ),to go back to clubbing with friends,to make love ,to have long walks ... i am very grateful to Prof Villafane...i told him that i did not understand why his protocol was not more wide spread...he told me straight in the eyes ,that this Nicotine protocol was not very expensive,easy to teach,easy to receive,all things Big Pharma labos are not very interested in ! Voila dear comrades,the results i wanted to share with you. kind regards |
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02-13-2012, 08:31 AM
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fascinating subject.
"Hello all This is a really intriguing area of research. These early studies using nicotine patches are showing some encouraging results. But we need much larger and longer studies before we know for sure whether nicotine patches are safe and effective for people with Parkinson's to use as a long term treatment. Until then, people should not start using nicotine patches without the explicit recommendation of their doctor. Studies have shown that smoking slightly lowers risk of Parkinson's - but it doesn't prevent it absolutely. This suggests that the effects of nicotine may be quite subtle. The research we're funding at the University of Oxford (which Ezinda highlighted) is investigating the potential of nicotine to treat Parkinson's. The hope is that we can develop treatments that can harness and boost the beneficial effects of nicotine. Such treatments would help reduce distressing side effects such as impulsive and compulsive behaviours, and may even slow the development of the condition. Hope this helps to answer your questions. Best wishes Claire Senior Research Communications Officer" Take care, Neil. |
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| "Thanks for this!" says: | Conductor71 (02-23-2013), hiptothat (02-14-2012) |
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02-14-2012, 12:17 PM
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Senior Member
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Wikipedia states that Tyrosine Hydroxylase "is increased acutely (minutes) by phosphorylation and chronically (days) by protein synthesis. ... The phosphorylation can be sustained by nicotine for up to 48 hours."
"Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to dihydroxyphenylalanine (DOPA). . . . It does so using tetrahydrobiopterin as a coenzyme. DOPA is a precursor for dopamine, " http://en.wikipedia.org/wiki/Tyrosine_hydroxylase John
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Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg |
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02-05-2013, 07:48 PM
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Hi Villers I hope you are doing good my friend. I was wondering if you could give me an update on how you are doing with the nicotine patch. I haven't heard from you in over a year on the subject. I'm am thinking about doing it myself but that depends on you experience to date. Please reply to your thread or send me a message. Take care my friend.
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02-05-2013, 10:09 PM
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Junior Member
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John Diag. Mar 2008 YOPD, @ age 39 |
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exactly what I got too
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