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02-14-2012, 12:17 PM | #21 | ||
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Wikipedia states that Tyrosine Hydroxylase "is increased acutely (minutes) by phosphorylation and chronically (days) by protein synthesis. ... The phosphorylation can be sustained by nicotine for up to 48 hours."
"Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to dihydroxyphenylalanine (DOPA). . . . It does so using tetrahydrobiopterin as a coenzyme. DOPA is a precursor for dopamine, " http://en.wikipedia.org/wiki/Tyrosine_hydroxylase John
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Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg |
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02-05-2013, 07:48 PM | #22 | ||
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Hi Villers I hope you are doing good my friend. I was wondering if you could give me an update on how you are doing with the nicotine patch. I haven't heard from you in over a year on the subject. I'm am thinking about doing it myself but that depends on you experience to date. Please reply to your thread or send me a message. Take care my friend.
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02-05-2013, 08:53 PM | #23 | ||
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And look up " nicotinic receptor agonists" for the whole spiel of the theory of the acetylcholine esterase story, if you are into that sorta rot.!
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02-05-2013, 10:09 PM | #24 | |||
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Quote:
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John Diag. Mar 2008 YOPD, @ age 39 |
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03-02-2014, 08:35 PM | #25 | ||
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[QUOTE=krugen68;732493]i find that hard to believe since PD usually affects us in our 60s and 70s. that age group now was the one when almost everyone smoked. he must mean that his 499 other patients don't smoke NOW.
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03-03-2014, 03:20 AM | #26 | ||
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Junior Member
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hi drevy
where did do you read that you have to reach 60mg ....i never wrote that you must start at 3,5mg and add 3,5mg every 2 months...... starting at a bigger dose is counter-effective |
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03-04-2014, 05:27 AM | #27 | ||
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Junior Member
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yesterday,i had my appointment in the afternoon with Dr villafane ,i was very happy as it was my first meeting in 3 years since i started the Nicotine therapy , where i went without any Sinemet in my system...
i was functioning extremely well ! he was glad but not surprised...i asked him if there is a Dose to reach,he answered me that there is not such thing...i have currently reached the 35mg nicotine level since 2 months he said that he has patients doing very well at lower doses and other where bigger doses are needed,every case is different... he said also that Nicotine therapy has still a lot of problems to get recognition as the Big pharma labs are not so interested as they won't make big profits with it,and nicotine still has a very poor image as nicotine is falsely associated with cigarette diseases but nicotine in itself is not bad, it's the other additives in cigarettes which are provoking health problems . So for me,i should stay at 35 mg for the upcoming months . Drevy,let me apologize about the 60 mg,i had forgotten i had given (and was given ) this info 3 yrs ago... i am always scared if some PD comrades decide to do the Nicotine therapy by themselves and decide to start at a big dosage, which might not work . Last edited by villiers; 03-04-2014 at 06:00 AM. Reason: adding infos |
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10-18-2014, 01:37 AM | #28 | ||
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Hello Villiers,
I am new in this forum but I read almost all threads about Nicotine patch therapy. I have read your comments and reply and I have also search on a PUBMED, There are few studies with Nicotine patch therapy and everyone used different does, Can you please let me know how are you and how is your Parkinson since you have started (2010 as per your post) Nicotine patch therapy? What does of Nicotine are you on after 4 years? Does protocols allowed to go only up to 20 mg per day of Nicotine? Few studies I read - they have increased does much faster than the one you have mentioned and reached almost up to 105 mg per day, Your comments and experience is much appreciated, Thanks in advance, Quote:
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10-22-2014, 07:03 AM | #29 | ||
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Request for a reply from any experienced user of Nicotine Patch,
What next - once you have reached 20mg? Should we continue 20 mg per day or there are few studies on a pubmed which says about going up to 100 mg per day for few months, though no long term study available, Kindly reply, I am now about to reach 20 mg per day does. Quote:
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10-22-2014, 01:59 PM | #30 | ||
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If your at 21mg now or will be soon. Wait as per his instruction for the next titration which will be 24.5mg and so on. Follow his patching instructions and diet guideline. |
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