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02-27-2007, 02:00 PM
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In Remembrance
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I started a new thread to make sure it is seen...........Paula
From Dr. Todd Sherer at FOX Foundation: As we discussed, I feel that the BBB is worthy of further investigation in PD. What is really not understood at this time is whether BBB dysfunction is primary or secondary to the disease. That is, does PD result from BBB dysfunction allowing pathogens to enter the brain or is there a dysfunction in PD that then results in BBB dysfunction. It is also possible that drugs used to treat PD could cause some BBB dysfunction. While a lot of work has not focused on this issue, there has been some advances in recent years. I recommend you read some work by Nico Leenders from the Netherlands who has tried to image BBB function in PD patients. We have also funded him on a follow-up study that will be completing this fall. We have funded some other projects including work by Etienne Hirsch in Paris to look at the role of inflammation on BBB function in PD and also some recent work by Angela Cenci-Nilson from Sweden on the involvement of BBB dysfunction in the development of dyskinesia, a really novel hypothesis. Hope this information helps. |
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Response about BBB
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