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02-01-2011, 07:40 PM | #1 | ||
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News Gatherer
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AP - Scientists have identified five new genes linked to Parkinson's disease in a large genetic analysis of the illness, according to a new study. After reviewing nearly 8 million possible genetic mutations, researchers pinpointed five genes connected to Parkinson's disease. Previously, six other genes were identified, and experts say there is now increasing proof the degenerative disease is sparked by peoples' genes.
Read the full article... (From Yahoo) |
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"Thanks for this!" says: | olsen (02-01-2011) |
02-01-2011, 10:01 PM | #2 | |||
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Senior Member
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I have full text to this article. Scientists now conceding that genetics play a much bigger role than previously thought. The proof in the pudding...
haven't we heard this all before? The five "new" genes: The Lancet, Early Online Publication, 2 February 2011 The novel loci detected include biologically plausible candidate for Parkinson's disease risk. ACMSD is associated with picolinic and quinolinic acid homoeostasis and is a possible therapeutic target for several disorders that affect the CNS. The locus identified near STK39 has been associated with autism, hypertension, and inflammatory status, although there have been no reports of this locus contributing to neurodegenerative phenotypes. The LAMP3 locus might partly cause modulation of neuronal and neurosecretory function in PC12 cell lines. HLA-DRB5 is associated with multiple sclerosis, immunocompetence, and histocompatibility. The association with Parkinson's disease at HLA-DRB5 supports the theory that inflammatory factors are associated with the pathogenesis of Parkinson's disease. The protein product of HIP1R is functionally involved in intrinsic cell-death pathways and interacted with huntingtin to modulate polyglutamine-induced neuronal dysfunction in transgenic worm and mouse models. Finally, the association detected at the SYT11 locus includes a gene that has been investigated previously in a negative mutation screening study in 393 patients with familial or sporadic Parkinson's disease and in a cell biology study that showed an interaction between the protein products of SYT11 and PARK2 in patients with Parkinson's disease. Last edited by Conductor71; 02-01-2011 at 10:02 PM. Reason: correct link |
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02-02-2011, 04:43 AM | #3 | ||
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I was hoping this was not true. I just bought 3 pair, now I need new ones!
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