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all about Gaba

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Old 02-16-2011, 12:29 AM   #1
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Default all about Gaba



"Gamma-Amino Butyric acid (GABA) is an amino acid which acts as a neurotransmitter in the central nervous system. It inhibits nerve transmission in the brain, calming nervous activity"

"Other ways to skin the cat: other ways to increase GABA effect

Another approach is to look at substances which change GABA action in the brain. There seems to be more and better clinical research on the use of many of these substances in humans than there is on GABA. There are numerous natural substances which affect GABA. In fact understanding GABA helps explain the action of many commonly used herbs, vitamins and minerals.
Valerian root has a long history of use as a tranquilizer and works by increasing the effect of GABA on its receptors [30] American Ginseng also acts on the GABA receptors. [31] So does Kava Kava. [32] "

" The fragrance of Oolong tea has a similar effect, increasing GABA action. [35] Extracts of green tea, black tea and oolong tea elicit a GABA response in test models. [36] Epigallocatechin gallate extracts from tea had the opposite effect, inhibiting the GABA response. Coffee extracts also inhibit GABA response. [37] Magnesium binds to GABA sites and increases effect. [38] Taurine protects against glutamate overstimulation. [39] [40] Its inhibitory effect may act as anxiolytic. [41] "
"Serotonin is another neurotransmitter and it enhances GABA. Therefore, as precursors to serotonin, Tryptophan and 5-HTP increase GABA action. "

"Theanine is an amino acid found in large amounts in tea. It is why a cup of tea can be calming despite the fact it contains caffeine. Theanine may increase glutamate transport [42] and increase GABA levels. "
"The vitamin B6 derivative pyridoxal phosphate is a cofactor in the synthesis of GABA. Some people have trouble converting Vitamin B-6 to pyridoxal phosphate and for those people taking this active B-6 may increase GABA levels."
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Old 02-16-2011, 12:36 PM   #2
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Default Paula:

My interest in Gaba is because I think it plays a major role in reducing stress which in turn aggravates tremor (my main PD symptom).
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Old 02-16-2011, 02:44 PM   #3
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Default major inhibitory transmitter

As you probably know the Neruologix team is working on gene therapy targeting gaba. it has to be extremely important because we [well I do anyway] always seem to be so wound tight. Gaba is the body's "tranquilizer".

Thanks for the informative link!

"Time is not neutral for those who have pd or for those who will get it."
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